Term Name: |
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity |
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Search Ontology:
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Synonyms: |
- disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
- inhibition by virus of host STAT activity
- suppression by virus of host JAK-STAT cascade via inhibition of STAT activity
- suppression by virus of host signal transducer and activator of transcription activity
- suppression by virus of host STAT activity
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Definition: |
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
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References: |
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Ontology: |
GO: Biological Process
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AmiGO
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