ZFIN GO: Biological Process: cell surface receptor signaling pathway via JAK-STAT

OBO ID: GO:0007259

Term Name:	cell surface receptor signaling pathway via JAK-STAT		Search Ontology:
Synonyms:	JAK-STAT cascade JAK-STAT signal transduction receptor signaling pathway via JAK-STAT
Definition:	A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. 12039028
References:	Wikipedia:JAK-STAT_signaling_pathway
Ontology:	GO: Biological Process QuickGO AmiGO

Relationships

has parts:	tyrosine phosphorylation of STAT protein tyrosine phosphorylation of STAT protein Show first 5 Terms
is a type of:	cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT Show first 5 Terms
negatively regulated by:	negative regulation of receptor signaling pathway via JAK-STAT negative regulation of receptor signaling pathway via JAK-STAT Show first 5 Terms
positively regulated by:	positive regulation of receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via JAK-STAT Show first 5 Terms
regulated by:	regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT Show first 5 Terms

PHENOTYPE