OBO ID: GO:0005085

Term Name:	guanyl-nucleotide exchange factor activity		Search Ontology:
Synonyms:	ARF guanyl-nucleotide exchange factor activity cAMP-dependent guanyl-nucleotide exchange factor activity GDP-dissociation stimulator activity GDS GEF GNRP guanyl-nucleotide release factor activity guanyl-nucleotide releasing factor Rab guanyl-nucleotide exchange factor activity Rac guanyl-nucleotide exchange factor activity Ral guanyl-nucleotide exchange factor activity Ran guanyl-nucleotide exchange factor activity Rap guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanine nucleotide exchange factor Rho guanyl-nucleotide exchange factor activity RhoGEF Sar guanyl-nucleotide exchange factor activity
Definition:	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. (2)
References:	Reactome:R-HSA-109807 Reactome:R-HSA-109817 Reactome:R-HSA-114544 Reactome:R-HSA-1168636 Reactome:R-HSA-1225951 Reactome:R-HSA-1225957 Reactome:R-HSA-1250383 Reactome:R-HSA-1250463 Reactome:R-HSA-1250498 Reactome:R-HSA-1306972 Reactome:R-HSA-1433415 Reactome:R-HSA-1433471 Reactome:R-HSA-156913 Reactome:R-HSA-169904 Reactome:R-HSA-170979 Reactome:R-HSA-171026 Reactome:R-HSA-177938 Reactome:R-HSA-177945 Reactome:R-HSA-180687 Reactome:R-HSA-186834 Reactome:R-HSA-187746 Reactome:R-HSA-194518 Reactome:R-HSA-2029445 Reactome:R-HSA-2029451 Reactome:R-HSA-2029467 Reactome:R-HSA-203977 Reactome:R-HSA-205039 Reactome:R-HSA-210977 Reactome:R-HSA-2179407 Reactome:R-HSA-2424476 Reactome:R-HSA-2424477 Reactome:R-HSA-2485180 Reactome:R-HSA-2730840 Reactome:R-HSA-350769 Reactome:R-HSA-354173 Reactome:R-HSA-379044 Reactome:R-HSA-379048 Reactome:R-HSA-380073 Reactome:R-HSA-389348 Reactome:R-HSA-389350 Reactome:R-HSA-392054 Reactome:R-HSA-392195 Reactome:R-HSA-3928592 Reactome:R-HSA-3928612 Reactome:R-HSA-3928628 Reactome:R-HSA-3928632 Reactome:R-HSA-3928633 Reactome:R-HSA-3928642 Reactome:R-HSA-3928651 Reactome:R-HSA-392870 Reactome:R-HSA-3965444 Reactome:R-HSA-399938 Reactome:R-HSA-399995 Reactome:R-HSA-4093336 Reactome:R-HSA-416530 Reactome:R-HSA-416588 Reactome:R-HSA-418579 Reactome:R-HSA-418850 Reactome:R-HSA-418856 Reactome:R-HSA-419166 Reactome:R-HSA-420883 Reactome:R-HSA-428535 Reactome:R-HSA-428750 Reactome:R-HSA-428917 Reactome:R-HSA-442273 Reactome:R-HSA-442291 Reactome:R-HSA-442314 Reactome:R-HSA-442732 Reactome:R-HSA-445064 Reactome:R-HSA-5218829 Reactome:R-HSA-5218839 Reactome:R-HSA-5218850 Reactome:R-HSA-5617816 Reactome:R-HSA-5623508 Reactome:R-HSA-5623521 Reactome:R-HSA-5637806 Reactome:R-HSA-5637808 Reactome:R-HSA-5654392 Reactome:R-HSA-5654402 Reactome:R-HSA-5654413 Reactome:R-HSA-5654426 Reactome:R-HSA-5654600 Reactome:R-HSA-5654618 Reactome:R-HSA-5654647 Reactome:R-HSA-5654663 Reactome:R-HSA-5655241 Reactome:R-HSA-5655277 Reactome:R-HSA-5655326 Reactome:R-HSA-5655347 Reactome:R-HSA-5672965 Reactome:R-HSA-5686071 Reactome:R-HSA-5686318 Reactome:R-HSA-5694409 Reactome:R-HSA-6807868 Reactome:R-HSA-6811414 Reactome:R-HSA-6811418 Reactome:R-HSA-6811429 Reactome:R-HSA-749453 Reactome:R-HSA-751029 Reactome:R-HSA-825631 Reactome:R-HSA-8848618 Reactome:R-HSA-8850041 Reactome:R-HSA-8851827 Reactome:R-HSA-8851877 Reactome:R-HSA-8851899 Reactome:R-HSA-8875318 Reactome:R-HSA-8875320 Reactome:R-HSA-8875568 Reactome:R-HSA-8875591 Reactome:R-HSA-8876188 Reactome:R-HSA-8876190 Reactome:R-HSA-8876191 Reactome:R-HSA-8876193 Reactome:R-HSA-8876454 Reactome:R-HSA-8876615 Reactome:R-HSA-8876616 Reactome:R-HSA-8876837 Reactome:R-HSA-8877308 Reactome:R-HSA-8877311 Reactome:R-HSA-8877451 Reactome:R-HSA-8877475 Reactome:R-HSA-8877612 Reactome:R-HSA-8877760 Reactome:R-HSA-8877813 Reactome:R-HSA-8877998 Reactome:R-HSA-8964604 Reactome:R-HSA-8980691 Reactome:R-HSA-8982637 Reactome:R-HSA-8982640 Reactome:R-HSA-9013023 Reactome:R-HSA-9013109 Reactome:R-HSA-9013143 Reactome:R-HSA-9013159 Reactome:R-HSA-9013435 Reactome:R-HSA-9014296 Reactome:R-HSA-9014433 Reactome:R-HSA-9017491 Reactome:R-HSA-9018747 Reactome:R-HSA-9018768 Reactome:R-HSA-9018804 Reactome:R-HSA-9018817 Reactome:R-HSA-9018825 Reactome:R-HSA-9026891 Reactome:R-HSA-9029158 Reactome:R-HSA-9032067 Reactome:R-HSA-9032798 Reactome:R-HSA-9033292 Reactome:R-HSA-9036301 Reactome:R-HSA-939265 Reactome:R-HSA-9607304 Reactome:R-HSA-9619803 Reactome:R-HSA-9624845 Reactome:R-HSA-9634418 Reactome:R-HSA-9639286 Reactome:R-HSA-9640167 Reactome:R-HSA-9660824 Reactome:R-HSA-9664991 Reactome:R-HSA-9665009 Reactome:R-HSA-9665404 Reactome:R-HSA-9665408 Reactome:R-HSA-9665700 Reactome:R-HSA-9665707 Reactome:R-HSA-9666428 Reactome:R-HSA-9666430 Reactome:R-HSA-9670436 Reactome:R-HSA-9672163 Reactome:R-HSA-9672170 Reactome:R-HSA-9680385 Reactome:R-HSA-9693111 Reactome:R-HSA-9695853 Reactome:R-HSA-9703441 Reactome:R-HSA-9751201
Ontology:	GO: Molecular Function    QuickGO    AmiGO