OBO ID: CHEBI:9516

Term Name:	thapsigargin		Search Ontology:
Synonyms:	(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester Tg Thapsigargin thapsigargine
Definition:	An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
References:	Beilstein:4649293 CAS:67526-95-8 KEGG:C09561 KNApSAcK:C00003375 LIPID_MAPS_instance:LMPR0103410001 PDBeChem:TG1 PMID:10477042 PMID:12410314 PMID:16874404 PMID:17825049 PMID:20357004 PMID:24598360 PMID:9014219 Reaxys:4649293 Wikipedia:Thapsigargin
Ontology:	ChEBI  ( EBI )