Term Name: |
SU4312 |
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Search Ontology:
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Synonyms: |
- 3-(4-dimethylamino-benzylidenyl)-2-indolinone
- 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one
- 3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
- DMBI
- SU 4312
- SU-4312
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Definition: |
A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
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References: |
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Ontology: |
ChEBI
(
EBI
)
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