ZFIN ChEBI: tenofovir alafenamide

OBO ID: CHEBI:90926

Term Name:	tenofovir alafenamide		Search Ontology:
Synonyms:	GS 7340 GS-7340 propan-2-yl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate TAF tenofovir alafenamide
Definition:	An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection.
References:	CAS:379270-37-8 DrugBank:DB09299 Drug_Central:4944 KEGG:D10428 Reaxys:8948831 Wikipedia:Tenofovir_alafenamide
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	6-aminopurines ether isopropyl ester L-alanine derivative phosphoramidate ester 6-aminopurines ether isopropyl ester L-alanine derivative phosphoramidate ester Show first 5 Terms
has_functional_parent:	adenine adenine Show first 5 Terms
has_role:	antiviral drug HIV-1 reverse transcriptase inhibitor prodrug antiviral drug HIV-1 reverse transcriptase inhibitor prodrug Show first 5 Terms
inverse is_conjugate_acid_of:	tenofovir alafenamide(1+) tenofovir alafenamide(1+) Show first 5 Terms
is_conjugate_base_of:	tenofovir alafenamide(1+) tenofovir alafenamide(1+) Show first 5 Terms

PHENOTYPE No data available