OBO ID: CHEBI:74498

Term Name:	5-fluoroorotic acid		Search Ontology:
Synonyms:	1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid 5-fluoro-6-carboxyuracil 5-fluorouracil-4-carboxylic acid ENT-26398 FO FOA NSC 31712 NSC-31712 Ro 2-9945
Definition:	A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells.
References:	CAS:703-95-7 PMID:2675756 PMID:3323810 PMID:3586772 Patent:GB806584 Patent:US2948725 Reaxys:181933
Ontology:	ChEBI  ( EBI )