OBO ID: CHEBI:63959

Term Name:	celastrol		Search Ontology:
Synonyms:	(2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)- Tripterine
Definition:	A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
References:	CAS:34157-83-0 HMDB:HMDB0002385 PMID:11809076 PMID:15593077 PMID:20934245 PMID:20954803 PMID:21134410 PMID:21414301 PMID:21425580 PMID:21466843 PMID:21569548 PMID:21666907 PMID:21850367 PMID:21865725 PMID:21866552 PMID:22087583 PMID:22206928 PMID:22334592 Patent:KR20100097843 Patent:US2011263693 Reaxys:2194425
Ontology:	ChEBI  ( EBI )