OBO ID: CHEBI:145430

Term Name:	ivosidenib		Search Ontology:
Synonyms:	(2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide AG-120 ivosidenib ivosidenibum N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxo-L-prolinamide Tibsovo
Definition:	A tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation.
References:	CAS:1448347-49-6 DrugBank:DB14568 KEGG:D11090 PMCID:PMC6217633 PMID:27245312 PMID:29670690 PMID:29860938 PMID:29925981 PMID:29934313 PMID:30093505 PMID:30209701 PMID:30222290 PMID:30231226 PMID:30260154 PMID:30260155 PMID:30610623 PMID:30692099 PMID:30758648 PMID:30822797 PMID:31011758 PMID:31028664 PMID:31300360 PMID:31382862 Wikipedia:Ivosidenib
Ontology:	ChEBI  ( EBI )