ZFIN ChEBI: phosphonoformic acid

OBO ID: CHEBI:127780

Term Name:	phosphonoformic acid		Search Ontology:
Synonyms:	carboxyphosphonic acid dihydroxyphosphanecarboxylic acid oxide Foscarmet foscarnet PHOSPHONOFORMIC ACID phosphonomethanoic acid
Definition:	Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
References:	CAS:4428-95-9 DrugBank:DB00529 Drug_Central:1241 HMDB:HMDB0014670 KEGG:C06456 KNApSAcK:C00000800 PDBeChem:PPF PMID:11576919 PMID:15182735 PMID:16858125 PMID:19213941 PMID:19288498 PMID:21056575 PMID:21566148 PMID:7518199 Reaxys:1756501 Wikipedia:Foscarnet
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	carboxylic acid one-carbon compound phosphonic acids carboxylic acid one-carbon compound phosphonic acids Show first 5 Terms
has_functional_parent:	formic acid phosphonic acid formic acid phosphonic acid Show first 5 Terms
has_role:	antiviral drug geroprotector HIV-1 reverse transcriptase inhibitor sodium-dependent Pi-transporter inhibitor antiviral drug geroprotector HIV-1 reverse transcriptase inhibitor sodium-dependent Pi-transporter inhibitor Show first 5 Terms
inverse has_functional_parent:	CMP-5'-phosphonoformic acid CMP-5'-phosphonoformic acid Show first 5 Terms
inverse is_conjugate_base_of:	phosphonatoformate phosphonoformate(2-) phosphonatoformate phosphonoformate(2-) Show first 5 Terms
is_conjugate_acid_of:	phosphonatoformate phosphonoformate(2-) phosphonatoformate phosphonoformate(2-) Show first 5 Terms

PHENOTYPE No data available