| Term: | astrocyte nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | astrocyte |
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| Synonyms: | astrocytes |
| Definition: | A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury. |
| Ontology: | Anatomy Ontology [ZFA:0009075] |
| Name: | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
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| Synonyms: | NLR signaling pathway, NOD-like receptor signaling pathway, nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway, nucleotide-binding domain, leucine rich repeat containing receptor signal transduction, nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway, nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway |
| Definition: | The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. |
| Ontology: | GO: Biological Process [GO:0035872] QuickGO AmiGO |