| Term: | macrophage nuclear receptor activity |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | macrophage |
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| Synonyms: | histiocyte |
| Definition: | A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. |
| Ontology: | Anatomy Ontology [ZFA:0009141] |
| Name: | nuclear receptor activity |
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| Synonyms: | 1,25-(OH)2D3 receptor activity, 9-cis retinoic acid receptor activity, androgen receptor activity, calcitriol receptor activity, ecdysteroid hormone receptor activity, glucocorticoid receptor activity, juvenile hormone receptor activity, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-dependent nuclear receptor activity, ligand-dependent transcription factor activity, nuclear hormone receptor, retinoic acid receptor activity, retinoid-X receptor activity, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding, RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, RXR, thyroid hormone receptor activity, vitamin A receptor activity, vitamin D receptor activity, vitamin D3 receptor activity |
| Definition: | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. |
| Ontology: | GO: Molecular Function [GO:0004879] QuickGO AmiGO |