Gene

slc4a3

ID

ZDB-GENE-141006-1

Name

solute carrier family 4 member 3

Symbol

slc4a3 Nomenclature History

Previous Names

Ae3 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have inorganic anion exchanger activity. Involved in cardiac muscle cell action potential. Predicted to localize to integral component of membrane. Used to study short QT syndrome. Is expressed in fin and fin bud. Orthologous to human SLC4A3 (solute carrier family 4 member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Shmukler et al., 2014

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thorsen et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc4a3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Short QT syndrome 7	620231

Associated With slc4a3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
short QT syndrome	AB + MO1-slc4a3	standard conditions	Thorsen et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018241	Anion exchange, conserved site
Domain	IPR011531	Bicarbonate transporter-like, transmembrane domain
Domain	IPR013769	Band 3 cytoplasmic domain
Family	IPR001717	Anion exchange protein
Family	IPR003020	Bicarbonate transporter, eukaryotic
Homologous_superfamily	IPR016152	Phosphotransferase/anion transporter

Domain Details Per Protein

Protein	Length	Anion exchange, conserved site	Anion exchange protein	Band 3 cytoplasmic domain	Bicarbonate transporter, eukaryotic	Bicarbonate transporter-like, transmembrane domain	Phosphotransferase/anion transporter
UniProtKB:A0A0G2KM71 InterPro	739
UniProtKB:A0A096X8J7 InterPro	1170
UniProtKB:A0A8M6Z7Y3 InterPro	1005
UniProtKB:A0A8M9PRV8 InterPro	1015
UniProtKB:A0A8M3AWC1 InterPro	1229

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations