Gene

hpgd

ID

ZDB-GENE-080728-2

Name

15-hydroxyprostaglandin dehydrogenase

Symbol

hpgd Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to act upstream of or within prostaglandin metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hpgd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary hypertrophic osteoarthropathy	Alliance	Cranioosteoarthropathy	259100
primary hypertrophic osteoarthropathy	Alliance	Hypertrophic osteoarthropathy, primary, autosomal recessive 1	259100
		?Digital clubbing, isolated congenital	119900

Associated With hpgd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020904	Short-chain dehydrogenase/reductase, conserved site
Family	IPR002347	Short-chain dehydrogenase/reductase SDR
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily