Gene
amer1
- ID
- ZDB-GENE-070719-2
- Name
- APC membrane recruitment protein 1
- Symbol
- amer1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; caudal fin; central nervous system; digestive system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in colorectal cancer and osteopathia striata with cranial sclerosis. Orthologous to human AMER1 (APC membrane recruitment protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteopathia striata with cranial sclerosis | Alliance | Osteopathia striata with cranial sclerosis | 300373 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019003 | APC membrane recruitment protein |
Domain Details Per Protein
| Protein | Additional Resources | Length | APC membrane recruitment protein |
|---|---|---|---|
| UniProtKB:A0A2R8RN23 | InterPro | 953 | |
| UniProtKB:F1RDM5 | InterPro | 930 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available