ZFIN is now using GRCz12tu for Genomic Data
Gene
tmc1
- ID
- ZDB-GENE-060526-261
- Name
- transmembrane channel-like 1
- Symbol
- tmc1 Nomenclature History
- Previous Names
-
- si:dkey-229d2.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mechanosensitive monoatomic ion channel activity and voltage-gated calcium channel activity. Acts upstream of or within cellular response to mechanical stimulus. Located in stereocilium bundle. Is expressed in anterior crista; inner ear; lateral crista; neuromast; and posterior crista. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Maeda et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 36 | Alliance | Deafness, autosomal dominant 36 | 606705 |
| autosomal recessive nonsyndromic deafness 7 | Alliance | Deafness, autosomal recessive 7 | 600974 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TMC domain | Transmembrane channel-like protein |
|---|---|---|---|---|
| UniProtKB:F1QFU0 | InterPro | 720 | ||
| UniProtKB:A0A5H1ZRH9 | InterPro | 990 | ||
| UniProtKB:A0A8M9PKH1 | InterPro | 990 | ||
| UniProtKB:A0AC58JK75 | InterPro | 986 | ||
| UniProtKB:A0AC58JK78 | InterPro | 778 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers