Gene

hsf4

ID

ZDB-GENE-050306-18

Name

heat shock transcription factor 4

Symbol

hsf4 Nomenclature History

Previous Names

zgc:113344

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Exhibits sequence-specific DNA binding activity. Involved in lens development in camera-type eye; positive regulation of deoxyribonuclease activity; and regulation of lens fiber cell differentiation. Predicted to localize to nucleus. Used to study cataract. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Is expressed in eye; lens; and solid lens vesicle. Orthologous to human HSF4 (heat shock transcription factor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hsf4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 5 multiple types	Alliance	Cataract 5, multiple types	116800

Associated With hsf4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	WT + MO1-hsf4	standard conditions	Cui et al., 2013
cataract	hsf4^hzu5/hzu5	standard conditions	Cui et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Domain	IPR010542	Vertebrate heat shock transcription factor, C-terminal domain
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily