Gene

klhl15

ID

ZDB-GENE-040801-99

Name

kelch-like family member 15

Symbol

klhl15 Nomenclature History

Previous Names

wu:fa66h10
zgc:101051

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to be involved in protein ubiquitination. Predicted to localize to Cul3-RING ubiquitin ligase complex and nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human KLHL15 (kelch like family member 15).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With klhl15 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 103	Alliance	Intellectual developmental disorder, X-linked 103	300982

Associated With klhl15 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR011705	BTB/Kelch-associated
Domain	IPR030597	Kelch-like protein 15, BTB/POZ domain
Domain	IPR047030	Kelch-like protein 15, BACK domain
Family	IPR017096	BTB-kelch protein
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR015915	Kelch-type beta propeller
Repeat	IPR006652	Kelch repeat type 1

Domain Details Per Protein

Protein	Length	BTB/Kelch-associated	BTB-kelch protein	BTB/POZ domain	Kelch-like protein 15, BACK domain	Kelch-like protein 15, BTB/POZ domain	Kelch repeat type 1	Kelch-type beta propeller	SKP1/BTB/POZ domain superfamily
UniProtKB:A0A8M3ANH9 InterPro	604
UniProtKB:A0A2R8QC44 InterPro	613
UniProtKB:F1R4M4 InterPro	654
UniProtKB:Q6DEL7 InterPro	604

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	klhl15-201 (1) Ensembl	Ensembl	2,860 nt	Select Tool
mRNA	klhl15-203 (1) Ensembl	Ensembl	4,938 nt	Select Tool ZFIN BLAST
mRNA	klhl15-204 (1) Ensembl	Ensembl	5,700 nt	Select Tool ZFIN BLAST
ncRNA	klhl15-002 (1) Ensembl	Ensembl	451 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations