Gene

parp1

ID
ZDB-GENE-030131-3955
Name
poly (ADP-ribose) polymerase 1
Symbol
parp1 Nomenclature History
Previous Names
  • si:dkey-206f10.3
  • wu:fc60f12
  • zgc:110092
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Predicted to be involved in double-strand break repair and protein poly-ADP-ribosylation. Predicted to localize to nucleolus. Human ortholog(s) of this gene implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With parp1 Human Ortholog
No data available
Associated With parp1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001357 BRCT domain
Domain IPR001510 Zinc finger, PARP-type
Domain IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
Domain IPR008893 WGR domain
Domain IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
Domain IPR012982 PARP1-like, PADR1 domain, zinc ribbon fold
Domain IPR049296 PARP1-like, PADR1 domain, N-terminal helical subdomain
Family IPR008288 Poly [ADP-ribose] polymerase
Family IPR050800 ADP-ribosyltransferase diphtheria toxin-like
Homologous_superfamily IPR036420 BRCT domain superfamily
Homologous_superfamily IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamily
Homologous_superfamily IPR036930 WGR domain superfamily
Homologous_superfamily IPR036957 Zinc finger, PARP-type superfamily
Homologous_superfamily IPR038650 PADR1, C-terminal domain superfamily
Domain Details Per Protein
Protein Length ADP-ribosyltransferase diphtheria toxin-like BRCT domain BRCT domain superfamily PADR1, C-terminal domain superfamily PARP1-like, PADR1 domain, N-terminal helical subdomain PARP1-like, PADR1 domain, zinc ribbon fold Poly [ADP-ribose] polymerase Poly(ADP-ribose) polymerase, catalytic domain Poly(ADP-ribose) polymerase, regulatory domain Poly(ADP-ribose) polymerase, regulatory domain superfamily WGR domain WGR domain superfamily Zinc finger, PARP-type Zinc finger, PARP-type superfamily
UniProtKB:A0A8N1TQ38
InterPro
1013
UniProtKB:Q5RHR0
InterPro
1013
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA parp1-201 (1)
Ensembl
Ensembl 3,802 nt
mRNA parp1-202 (1)
Ensembl
Ensembl 3,863 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-parp1 polyclonal Rabbit
  • WB
 1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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