ZFIN

ZFIN ID: ZDB-TGCONSTRCT-170616-4

CITATIONS (5 total)

Transgenic Construct Name:	Tg(UAS:Dendra2-Hsa.MAPT_A152T,myl7:EGFP)
Transgenic Construct Symbol:	Tg(UAS:Dendra2-Hsa.MAPT_A152T,myl7:EGFP)

Lesport, E., Commeau, L., Genet, M., Baulieu, E.E., Tawk, M., Giustiniani, J. (2024) A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo. Frontiers in Cellular Neuroscience. 18:14252221425222

Lopez, A., Siddiqi, F.H., Villeneuve, J., Ureshino, R.P., Jeon, H.Y., Koulousakis, P., Keeling, S., McEwan, W.A., Fleming, A., Rubinsztein, D.C. (2024) Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion. Nature Chemical Biology. :

VerPlank, J.J.S., Tyrkalska, S.D., Fleming, A., Rubinsztein, D.C., Goldberg, A.L. (2020) cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. 117(25):14220-14230

Siddiqi, F.H., Menzies, F.M., Lopez, A., Stamatakou, E., Karabiyik, C., Ureshino, R., Ricketts, T., Jimenez-Sanchez, M., Esteban, M.A., Lai, L., Tortorella, M.D., Luo, Z., Liu, H., Metzakopian, E., Fernandes, H.J.R., Bassett, A., Karran, E., Miller, B.L., Fleming, A., Rubinsztein, D.C. (2019) Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nature communications. 10:1817

Lopez, A., Lee, S.E., Wojta, K., Ramos, E.M., Klein, E., Chen, J., Boxer, A.L., Gorno-Tempini, M.L., Geschwind, D.H., Schlotawa, L., Ogryzko, N.V., Bigio, E.H., Rogalski, E., Weintraub, S., Mesulam, M.M., Fleming, A., Coppola, G., Miller, B.L., Rubinsztein, D.C. (2017) A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain : a journal of neurology. 140(4):1128-1146