Research
Search
Genes / Clones
Expression
Mutants / Tg
Antibodies
Anatomy / GO / Human Disease / Chemical
Publications
Data Mining
Downloads
Data Model
AllianceMine
BioMart
Genomics
BLAST
ZFIN
Ensembl
NCBI
UCSC
Genome Browsers
ZFIN
Ensembl
Vega
GRC
UCSC
NCBI
Resources
Zebrafish Genomics
Other Genome Databases
Resources
General
The Zebrafish Book
Protocol Wiki
Antibody Wiki
Anatomy Atlases
Resources for Students and Educators
Zebrafish Programs
ZF-Health
Husbandry Resources
More...
Resource Centers
Zebrafish International Resource Center (ZIRC)
China Zebrafish Resource Center (CZRC)
European Zebrafish Resource Center (EZRC)
Community
Announcements
News
Meetings
Jobs
Alliance Community Forum
Search
People
Labs
Companies
Societies
International Zebrafish Society (IZFS)
Zebrafish Disease Models Society (ZDMS)
Genetics Society of America (GSA)
Zebrafish Husbandry Association
Support
Nomenclature
Nomenclature Conventions
Line Designations
Wild-Type Lines
Submit a Proposed Gene Name
Submit a Proposed Mutant/Tg Line Name
Publications
Guidelines for Authors
Zebrashare
Citing ZFIN
Using ZFIN
Help & Tips
Glossary
Single Box Search Help
Submit Data
Terms of Use
About Us
About ZFIN
Contact Information
Statistics
Committees
Jobs at ZFIN
Sign In
Phenotype Figure Summary
Marker:
dmxl2
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Tuttle
et al.
, 2014
Fig. 2
ir937Tg + MO1-dmxl2 + MO1-tp53
, 
WT + MO1-dmxl2 + MO1-tp53
, 
dmxl2
t21192/t21192
melanoblast neural crest cell aggregated, abnormal
midbrain hindbrain boundary morphology, abnormal
neural crest cell migration decreased rate, abnormal
neural crest cell migration disrupted, abnormal
neural crest cell migration process quality, abnormal
neural crest cell mislocalised, abnormal
post-vent region decreased length, abnormal
post-vent region kinked, abnormal
xanthoblast neural crest cell aggregated, abnormal
Fig. 3
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell early endosome aggregated, abnormal
neural crest cell early endosome increased amount, abnormal
neural crest cell early endosome increased size, abnormal
neural crest cell endocytosis process quality, abnormal
neural crest cell endosome immature, abnormal
neural crest cell late endosome decreased amount, abnormal
neural crest cell late endosome decreased size, abnormal
Fig. 5
WT + MO1-dmxl2 + MO1-tp53
canonical Wnt signaling pathway decreased process quality, abnormal
Fig. S1
WT + MO1-dmxl2 + MO1-tp53
, 
dmxl2
t21192/t21192
melanocyte decreased amount, abnormal
pericardium edematous, abnormal
post-vent region curved, abnormal
post-vent region decreased length, abnormal
Fig. S2
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell aggregated, abnormal
neural crest cell migration disrupted, abnormal
neural crest cell mislocalised, abnormal
Fig. S3
ir937Tg + MO1-tp53 + MO2-dmxl2
, 
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell aggregated, abnormal
neural crest cell migration disrupted, abnormal
neural crest cell mislocalised, abnormal
Fig. S5
WT + MO1-dmxl2 + MO1-tp53
neural crest cell migration decreased rate, abnormal
Fig. S6
ir937Tg + MO1-dmxl2 + MO1-tp53
neural crest cell early endosome increased amount, abnormal
neural crest cell early endosome increased size, abnormal
Einhorn
et al.
, 2012
Fig. 1
dmxl2
t21010/t21010
, 
dmxl2
t26173/t26173
, 
dmxl2
t21192/t21192
sensory perception of sound decreased process quality, abnormal
Fig. 3
dmxl2
t26173/t26173
, 
dmxl2
t21192/t21192
neuromast hair cell synaptic vesicle lumen decreased acidity, abnormal
regulation of cellular pH reduction decreased process quality, abnormal
regulation of proton-transporting ATPase activity, rotational mechanism decreased process quality, abnormal
synaptic vesicle lumen acidification decreased process quality, abnormal
synaptic vesicle maturation decreased process quality, abnormal
Fig. 4
dmxl2
t21192/t21192
neuromast hair cell vacuolar proton-transporting V-type ATPase, V1 domain mislocalised, abnormal
Fig. 6
dmxl2
t21192/t21192
neuron-neuron synaptic transmission decreased process quality, abnormal
sensory perception of sound decreased process quality, abnormal
Your Input Welcome
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Name:
Institution:
Email address:
Please leave blank:
Subject:
Comments:
Send your comments
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.