FIGURE SUMMARY
Title

Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains

Authors
Blachowicz, A., Raffa, N., Bok, J.W., Choera, T., Knox, B., Lim, F.Y., Huttenlocher, A., Wang, C.C.C., Venkateswaran, K., Keller, N.P.
Source
Full text @ MBio
FIG 1

UV-C sensitivity and secondary metabolite profiles of Af293, ΔakuA mutant, and ΔakuA -mluc mutant strains. (A) Percent viability following exposure to various doses of UV-C radiation of control strains. (B) Secondary metabolite profiles of control strains.
FIG 2

UV-C sensitivity and secondary metabolite profiles of Af293 and Af293 DHN-melanin mutants in the intact and disrupted akuA backgrounds. (A) Percent viability following exposure to various doses of UV-C radiation for Af293 and the ΔpksP, ΔakuA, and ΔpksP ΔakuA mutants. (B) Secondary metabolite profiles of Af293 and the ΔpksP, ΔakuA, and ΔpksP ΔakuA mutants. Asterisks (*) indicate statistical significance using Welch’s corrected t test (details in Table S2).
FIG 3

UV-C sensitivity and secondary metabolite profiles of ISS-isolated IF1SW-F4, CEA17, and their DHN-melanin mutants. (A) Percent viability following exposure to various doses of UV-C radiation for IF1SW-F4 and IF1SW-F4 ΔpksP. (B) Secondary metabolite profiles of IF1SW-F4 and IF1SW-F4 ΔpksP. (C) Percent viability following exposure to various doses of UV-C radiation for CEA17 and CEA17 ΔpksP. (D) Secondary metabolite profiles of CEA17 and CEA17 ΔpksP. Asterisks (*) indicate statistical significance using Welch’s corrected t test (details in Table S2).
FIG 4

UV-C sensitivity and secondary metabolite profiles of conidium-associated SM mutants of Af293 in backgrounds with disrupted and intact akuA. (A to C) Percent viability following exposure to various doses of UV-C radiation for ΔdmaW (A), ΔtpcC (B), and ΔfmqA (C) mutants in Af293 with intact akuA. (D to F) Percent viability following exposure to various doses of UV-C radiation for ΔdmaW (D), ΔtpcC (E), and ΔfmqA (F) in Af293 with disrupted akuA. Asterisks (*) indicate statistical significance using Welch’s corrected t test (details in Table S2).
FIG 5

Virulence of DHN-melanin mutants of three Aspergillus fumigatus strains in a zebrafish model of invasive aspergillosis. (A) Percent survival of zebrafish upon infection with Af293 and the ΔpksP mutant. (B) Percent survival of zebrafish upon infection with CEA17 and the ΔpksP mutant. (C) Percent survival of zebrafish upon infection with IF1SW-F4 and ΔpksP mutant. P values were generated by Cox proportional hazards regression analysis. DPI, days postinfection.
FIG 6

Virulence of three conidial SM mutants of Aspergillus fumigatus in a zebrafish model of invasive aspergillosis. Percent survival of zebrafish upon infection with Af293 WT and the ΔdmaW, ΔtpcC, and ΔfmqA mutants. P values were generated by Cox proportional hazards regression analysis.
Acknowledgments
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