Genomic Feature
to79c
- ID
- ZDB-ALT-980413-567
- Name
- to79c
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 26847153 (GRCz11) (1) Details
- Nucleotide change
- C/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CAACAATAAGTTGGGCTCATAACTCAGCCACAGAATGTCTGAACTGCTTGAAACTTTACATGGTTGATAAAATTCCTCTACTGAAGGTATCTACATGCCAATCTTGAGTCACAGTCATAGCACCACCTGCTGACAGGAGAAAGTTTGGCATAAATGTGTGATTTTCTCATATATATCGGCCAAAATTAATATTGTTCGCTGTTCTCTGTCATCCTGAGGCCACCGGGGGCGGTGAGCCCGGGTGCGAGGTCCCTATCATCGCTGCTTGCAGCTTTAATTAATTTATTAAAATCATGTATGTCCTTGAGAACATTTAATGATATTCTCTGACATATGTTCATATACAGTACATCAGTGCTGTTAGTGTATTCTGAGGGGCTATTTTGTGTCCTTTCGCAGTGGTTTTGTCTGGACAGGCTCATCATGTGTGCATCAGGGAAGTACGGTTCACGGGGCCCTGCTCTCATACCCCGCATGAAGACTAAACACCGGATCTACTA
C/A ATCACCCTCTTCTCTGTGGTCTTGCTGGGATTGATCGCAACAGGGATGTTCCAGTTCTGGCCTCACTCCATTGAGTCTTCAGCCGAATGGAGTCTGGACCGCCGCAGTGTGCACGATGCTCCTTTGGTCAGGATTCCTGTGAACAGTCCTATTCCTGGGAGGGGTGACCTGAGCTGCCGGATGCACACCTGCTTTGATGTTTATCGCTGTGGATATAATCCTAAGAACAAAATCAAGGTAATGCACAAACAGAGAATGTCCTATCAAATTTTTTAAACTTGTTTGCTGGATGTCATCCCTGTGCATCTTTTAATTAAGAAAACTTGCAGTAGCATTTGCAAATTTGAAACATCATGTTAGTGAACATTCGGAATCAGCTCACGATGCACATTAAATAAACAAGCCACCTGTGAGAGACACAATCTTTCCTCTCCCTATGCATCAGACACTATAATAAACAATAAACACTCCATGTTTCTGAGCAATCCTGGGTGTGCTTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ext2to79c/to79c | Homozygous | ♀+/- ♂+/- | 7 figures from 4 publications | ||
| ext2to79c/to79c; zf106Tg | Complex | 2 figures  from Venero Galanternik et al., 2015 | 2 figures from Venero Galanternik et al., 2015 | ||
| ext2to79c/to79c; extl3tm70g/tm70g | Complex | 3 figures from Venero Galanternik et al., 2015 | |||
| ext2to79c/to79c; extl3tm70g/tm70g; zf106Tg | Complex | 3 figures from Venero Galanternik et al., 2015 | Fig. 1 from Venero Galanternik et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Venero Galanternik, M., Kramer, K.L., Piotrowski, T. (2015) Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Reports. 10(30):414-428
- Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K. (2006) A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. Developmental Biology. 297(1):1-13
- Lee, J.S., von der Hardt, S., Rusch, M.A., Stringer, S.E., Stickney, H.L., Talbot, W.S., Geisler, R., Nüsslein-Volhard, C., Selleck, S.B., Chien, C.B., and Roehl, H. (2004) Axon Sorting in the Optic Tract Requires HSPG Synthesis by ext2 (dackel) and extl3 (boxer). Neuron. 44(6):947-960
- Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(19):8603-8615
- Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8
- Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438
- Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
- Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England). 123:439-450
- van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:255-262
- Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254
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