Genomic Feature
m552
- ID
- ZDB-ALT-980203-739
- Name
- m552
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 38692253 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Trp>Stop at position 103 (1)
- Flanking Sequence
-
GAAGGTAATTTTACGCCATCTGACTCATTAAACTTATTGGACTCACATATACAGTATTCCTCCTATCCAGTCAGCAGTCCTGCTGATTATAACTTTGCCTGTGTATGAACTCCATGCAGGCAGCGACAACGCTGTGATATGGACTTTGCTAGGTCAGCTGAAGGAAGGAAACAGCAGGTCCCAATGGGTCAGATCCCCTCCATTTTTAGGGCTCAAGCTTTTGTTAGGTTAGACGAGCTTGGCTGCCAATTGTTCTCCACCCAAAATCATTACATCCGCAGTCACTTCTGAAAACATCTCACATGGTTCATGAGGTTTCCCAAGACTCACTCGATATGAAGCGCACCCTAGTGGCCATCTAAAATCCCCCCTACCTCAGTTTCAGTATTATTTGCAGTTTGACTGATTTACAGTACACATTTTCTAACTCGTTCTTCTTTAATTATCCAATACAGGACATTCACCAAAACCTTTACAAACCTCTACAAATGCAGCGGATT
G/A GAAGACCAGTATGACCTCAGATGAGACAACAGAACATCTTCAATCTGACACTGAGCTTACCCATAATGCGACCGCCCAATGGGAGAGTCCATCATCAGCATCTCACAGCATTACCAGCCACCATCCAGTAACAGAGACACGAACCGTGCGAGATGTAACAGATCTGATAGACATGGACACCACAGACTCAGTCTCCCACACTGATAGCACCTACATTTCCACAACCAACCGAGTTGGAGAACGCACACTGCTCTCAGTGATCTCCAACAGCACCTTTGCGTACACCCAGAACTCAAGCATCTCTGATGCAGAGTCTCAAACGTCCCCATGGGAGGAGAAGACATCAGGAGCCACCCAAGTCAATGAGGAAACTGAAGAAACTGTGTCAACAGTGTCCGAACAGACTGATCCCACTTTTGAAGACCGCAATATCACCAGTGCAACTCTGGAGACTGGGCGGTCAACATTATTCCAAGGCACTGAGTCACAGACAGGACAAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| heg1m552/m552 | Homozygous | ♀+/- ♂+/- | |||
| heg1m552/m552 (AB) | Homozygous | Unknown | 2 figures  from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Yin, J., Schellinx, N., Maggi, L., Gundel, K., Wiesner, C., Kotini, M.P., Lee, M., Phng, L.K., Belting, H.G., Affolter, M. (2024) Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1. Nature communications. 15:97149714
- Kannan, R.R., Iniyan, A.M., Vincent, S.G. (2015) Chemical genetic effects of Sargassum wightii during embryonic development in zebrafish. Indian journal of pharmacology. 47:195-8
- Renz, M., Otten, C., Faurobert, E., Rudolph, F., Zhu, Y., Boulday, G., Duchene, J., Mickoleit, M., Dietrich, A.C., Ramspacher, C., Steed, E., Manet-Dupé, S., Benz, A., Hassel, D., Vermot, J., Huisken, J., Tournier-Lasserve, E., Felbor, U., Sure, U., Albiges-Rizo, C., Abdelilah-Seyfried, S. (2015) Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins. Developmental Cell. 32:181-190
- Mably, J.D., Mohideen, M.A.P.K., Burns, C.G., Chen, J.-N., and Fishman, M.C. (2003) heart of glass regulates the concentric growth of the heart in zebrafish. Current biology : CB. 13(24):2138-2147
- Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development (Cambridge, England). 123:37-46
- Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England). 123:285-292
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