Genomic Feature
th26
- ID
- ZDB-ALT-980203-1775
- Name
- th26
- Synonyms
-
- H26E (1)
- th26e
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 18: 20495707 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Gly>Glu at position 130 (1)
- Flanking Sequence
-
GCTCTCCCAAGTTCAGCAAAGACTTCATTTGCACTATGATGTGTTTAAACAACTGTAGCTCTCACATAATAATAATAAAGTATGCTTGATGTCTGTTGTGGCATGAAAACAATTTTAGCACTAGTACTTTGTGTTGTCTACTGTAATATCAGGTTGCAATAGGATGGGCAACCCTTGAATGATTTTTTTTTTCTTTTTTTTGTATATTATCTAATTATTATCTGTACTTTTTGATAAAATCGTTTAATGAATGAACTAATCTCTATTGTTTTCTTCCCTCATGTACATGTAAATCATCCATCAGTTCTCCCTCGCTCAAATAAACACAGCTAGAGAGATGGAGGATCCGGACTACCTGACGGAGGGCTATTTGAACCTGGCACGCAGCAATGAGAAGCTTTGCGATTTCCAGAAGACGGTCTCATATTGTGAGACCTGCTTAAACATGCAAGGCACCACTGTTAGCCTGCAACTCAATGGGCAAGTGTGCTTAAGCATGG
G/A AAATGCCTACTTGGGCCTAAGTGTTTTCCAGAAGGCCTTAGTTAGCTATGAGAAGGCCCTACGATATGCTCACAACAATGACGACAAGATGCTGGAGTGCAGGGTCTGCTGCAGTTTGGGCAACTTCTACATCCAGCTTAAGGTATAACAACTACTATCTCATTTATCTTTTTGTGTATGTGTGTATTTATGTTTGCATGATTTAGAATAGTTGTACATTCTTAAAAGTGTCATTTCAATTTAATTGATAATACCAACCCAACGTTGGATTTGTCCATATTTGACCCAATATTGGGCTACAACAAGTCAGCACTTTAGAGTTTAGGAGCATTTAGGAGAGTATAAGGTTATCAAACTTAATAGATAATGAATGGAGGATTATGGAAATGGAAATTTTGCAGAGTAAAAATTACATTTAGGCTTCTTTAAAGTGTCAAATCTTTGTCTACTAAAGAAATGCACTTTAAAATAATGGTCGATTTGGTTAATGAGTTAAGCTT - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
rapsnth26/th26 | Homozygous | ♀+/- ♂+/- | 9 figures from 3 publications | 2 figures from Park et al., 2012 | |
rapsnth26/th26; ml2Tg | Complex | Fig. S3 from Gribble et al., 2018 | |||
rapsnth26/th26; zf484Tg | Complex | Fig. 2 from Wen et al., 2016 | Fig. 2 from Wen et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Walker, L.J., Roque, R.A., Navarro, M.F., Granato, M. (2021) Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle. Development (Cambridge, England). 148(21):
- Gribble, K.D., Walker, L.J., Saint-Amant, L., Kuwada, J.Y., Granato, M. (2018) The synaptic receptor Lrp4 promotes peripheral nerve regeneration. Nature communications. 9:2389
- Wen, H., Hubbard, J.M., Wang, W.C., Brehm, P. (2016) Fatigue in Rapsyn-Deficient Zebrafish Reflects Defective Transmitter Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:10870-10882
- Park, J.Y., Ikeda, H., Ikenaga, T., and Ono, F. (2012) Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(21):7356-7363
- Habeck, H., Odenthal, J., Walderich, B., Maischein, H.-M., Tübingen 2000 screen consortium, and Schulte-Merker, S. (2002) Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Current biology : CB. 12(16):1405-1412
- Ono, F., Shcherbatko, A., Higashijima, S.-I., Mandel, G., and Brehm, P. (2002) The zebrafish motility mutant twitch once reveals new roles for rapsyn in synaptic function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(15):6491-6498
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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