Genomic Feature
to273b
- ID
- ZDB-ALT-980203-1138
- Name
- to273b
- Synonyms
-
- AO73B (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one MNV (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- MNV
- Variant Location
- Chr 7: 26847225 - 26847226 (GRCz11) (1) Details
- Nucleotide change
- TG/AT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TTCCTCTACTGAAGGTATCTACATGCCAATCTTGAGTCACAGTCATAGCACCACCTGCTGACAGGAGAAAGTTTGGCATAAATGTGTGATTTTCTCATATATATCGGCCAAAATTAATATTGTTCGCTGTTCTCTGTCATCCTGAGGCCACCGGGGGCGGTGAGCCCGGGTGCGAGGTCCCTATCATCGCTGCTTGCAGCTTTAATTAATTTATTAAAATCATGTATGTCCTTGAGAACATTTAATGATATTCTCTGACATATGTTCATATACAGTACATCAGTGCTGTTAGTGTATTCTGAGGGGCTATTTTGTGTCCTTTCGCAGTGGTTTTGTCTGGACAGGCTCATCATGTGTGCATCAGGGAAGTACGGTTCACGGGGCCCTGCTCTCATACCCCGCATGAAGACTAAACACCGGATCTACTACATCACCCTCTTCTCTGTGGTCTTGCTGGGATTGATCGCAACAGGGATGTTCCAGTTCTGGCCTCACTCCAT
TG/AT AGTCTTCAGCCGAATGGAGTCTGGACCGCCGCAGTGTGCACGATGCTCCTTTGGTCAGGATTCCTGTGAACAGTCCTATTCCTGGGAGGGGTGACCTGAGCTGCCGGATGCACACCTGCTTTGATGTTTATCGCTGTGGATATAATCCTAAGAACAAAATCAAGGTAATGCACAAACAGAGAATGTCCTATCAAATTTTTTAAACTTGTTTGCTGGATGTCATCCCTGTGCATCTTTTAATTAAGAAAACTTGCAGTAGCATTTGCAAATTTGAAACATCATGTTAGTGAACATTCGGAATCAGCTCACGATGCACATTAAATAAACAAGCCACCTGTGAGAGACACAATCTTTCCTCTCCCTATGCATCAGACACTATAATAAACAATAAACACTCCATGTTTCTGAGCAATCCTGGGTGTGCTTCACACAGGTGAGTGGGCTTGGCAATCACTCATAAGGAAACATACTCTTTCCTCTATCAGGCTGTATTTACACTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ext2to273b/to273b | Homozygous | ♀+/- ♂+/- | 40 figures  from 15 publications | 14 figures from 6 publications | |
| ext2to273b/+ | Heterozygous | ♀+/- ♂+/- | 2 figures from Wiweger et al., 2012 | ||
| ext2to273b/to273b; la6Tg | Complex | Fig. 3 from Volpi et al., 2017 | |||
| ext2to273b/to273b; la203Tg; zf154Tg | Complex | Fig. 5 from Wang et al., 2012 | |||
| ext2to273b/to273b; zf132Tg | Complex | ||||
| ext2to273b/to273b; la203Tg; zf154Tg + MO1-ptprfb | Complex | Fig. 7 from Wang et al., 2012 | |||
| ext2to273b/to273b; la203Tg; zf154Tg + MO2-ptprfb | Complex | Fig. 7 from Wang et al., 2012 | |||
| ext2to273b/to273b; la203Tg; zf154Tg + MO1-ptprfa + MO1-ptprfb | Complex | Fig. 7 from Wang et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Khalil, R., Lalai, R.A., Wiweger, M.I., Avramut, C.M., Koster, A.J., Spaink, H.P., Bruijn, J.A., Hogendoorn, P.C.W., Baelde, H.J. (2019) Glomerular permeability is not affected by heparan sulfate glycosaminoglycan deficiency in zebrafish embryos. American journal of physiology. Renal physiology. 317(5):F1211-F1216
- Di Donato, V., De Santis, F., Albadri, S., Auer, T.O., Duroure, K., Charpentier, M., Concordet, J.P., Gebhardt, C., Del Bene, F. (2018) An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System. Neuron. 97(5):1049-1062.e6
- Volpi, S., Yamazaki, Y., Brauer, P.M., van Rooijen, E., Hayashida, A., Slavotinek, A., Sun Kuehn, H., Di Rocco, M., Rivolta, C., Bortolomai, I., Du, L., Felgentreff, K., Ott de Bruin, L., Hayashida, K., Freedman, G., Marcovecchio, G.E., Capuder, K., Rath, P., Luche, N., Hagedorn, E.J., Buoncompagni, A., Royer-Bertrand, B., Giliani, S., Poliani, P.L., Imberti, L., Dobbs, K., Poulain, F.E., Martini, A., Manis, J., Linhardt, R.J., Bosticardo, M., Rosenzweig, S.D., Lee, H., Puck, J.M., Zúñiga-Pflücker, J.C., Zon, L., Park, P.W., Superti-Furga, A., Notarangelo, L.D. (2017) EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.. The Journal of experimental medicine. 214(3):623-637
- Wiweger, M.I., de Andrea, C.E., Scheepstra, K.W., Zhao, Z., Hogendoorn, P.C. (2014) Possible effects of EXT2 on mesenchymal differentiation--lessons from the zebrafish. Orphanet journal of rare diseases. 9:35
- Poulain, F.E., and Chien, C.B. (2013) Proteoglycan-mediated axon degeneration corrects pretarget topographic sorting errors. Neuron. 78(1):49-56
- Wang, F., Wolfson, S.N., Gharib, A., and Sagasti, A. (2012) LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin. Current biology : CB. 22(5):373-382
- Wiweger, M.I., Zhao, Z., van Merkesteyn, R.J., Roehl, H.H., and Hogendoornm, P.C. (2012) HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas. PLoS One. 7(1):e29734
- de Andrea, C.E., Prins, F.A., Wiweger, M.I., and Hogendoorn, P.C. (2011) Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. The Journal of pathology. 224(2):160-168
- Wiweger, M.I., Avramut, C.M., de Andrea, C.E., Prins, F.A., Koster, A.J., Ravelli, R.B., and Hogendoorn, P.C. (2011) Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders. The Journal of pathology. 223(4):531-542
- Xiao, T., Staub, W., Robles, E., Gosse, N.J., Cole, G.J., and Baier, H. (2011) Assembly of Lamina-Specific Neuronal Connections by Slit Bound to Type IV Collagen. Cell. 146(1):164-176
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