Genomic Feature
mdi4
- ID
- ZDB-ALT-210415-5
- Name
- mdi4
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Coffman Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 14: 23765857 - 23765876 (GRCz11) (1) Details
- Nucleotide change
- GACGATGTGGCAGTGCTGTC/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 20 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TAAAACAACTAAATCTTTTCCCCTTTGAACACAATATATTTTATTTTAAAAAACATGTTTTAGAGCAGTAAACATGTCAGGCTAAATAATTCAAATAAATCATTGACTTTAATTAGTTTCTAAAACACAGATTTCTTTACAATTTAAAACGACATGCTTTTCCGCAGGTGATACTGTTGTCCTAAAAATATGCAAATAAAAAATCTAACATATACCTTAGAAACATTATAGCTGAATATTTTGGCAATTTTAAAACCTTGACTTTTCCAAACTGCGGTAACCCTTGAAAACGATTATAGTCTCATCCCTATACTCAAGATGGACTTATAAAAAGAGAATGCATAGTAAACACATTAATGCCAGAGATATATGGAATACCTTCAACAGCCCTTTTAAAGAAGACTTTACAGCTTCCGCAAGTGAGAACTCCATAATGGCAGCCAGAAGCCTCATCTGAGCAAACCAGACAGATCTTGTGTGTGCCAGTCTTTCCACCAGCT
GACGATGTGGCAGTGCTGTC/- TTCAGGCCTGAAACAATCAGAAATATCTATCTTTTAATGTCCAGGAATATTATAGTGCTATCATTTTGAATATTGAACTGAAATGTACACTGCTGCCTGAAAGTTTGGGATCAGTAAAATTAGGGCAGGGCGATTTATCGAAAAGTAATCAAAATACACATTCAGAAACTATAATCAGTCAAAACATTTTTCAGGTGAATTTTTTCCAATTATTTTCCATACCATGTGTGGAGTCACGTGACCCCGCTTTAAGGCTAATTTCTACTTATTATATCATGATTTACACGTATTATATTATTCTGATACTATACTTCAGCCAAGTGCATGCCTATGGTCCGGTGCAGCCTCCGCATACCCATACACCTCTCAAAAAAAGAAATGTAACTACATGCAACAATGATGCGTAACGCAAGCTTTGTAATTGGTCGGTTTGGTAGCTGTGTCGAGGGTGGGGTGGACGGTGCAGAGAGCCGCATTTTATACAATCCGTGTTTTCAATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| nr3c1mdi4/mdi4 (AB) | Homozygous | ♀+/- ♂+/- | text only from Gans et al., 2020 | ||
| nr3c1mdi4/mdi4 (AB) | Homozygous | Unknown | FIGURE 1  from Gans et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Gans, I.M., Grendler, J., Babich, R., Jayasundara, N., Coffman, J.A. (2021) Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism. Frontiers in cell and developmental biology. 9:727037
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
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