Genomic Feature
ltu1
- ID
- ZDB-ALT-180522-1
- Name
- ltu1
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Dworkin Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 17: 26968290 - 26968292 (GRCz11) (1) Details
- Nucleotide change
- GTC/TTAATTAAGCTGTTGTA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 17 bp inserted / 3 bp deleted from position 26968290 to 26968304 in Exon 4 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: at position 143 (1)
- Flanking Sequence
-
AAAAATAGCAGCCTACAGAGCTTGTTGGTCTCCCCGATGTCAAACCCTGCCGAGAAACTCAAACAGTAAAAAAAAGTCAGCGTTAGGTGGCAAACAGCTCCCGCCCAATGTGTTTGGCTTGGCTTTTCACGCACTGAAAGCTCCATAAACAATGCGGAGATTGAGTAAAGCTTTTTATTGACTTTGACACATTTTTTGTGATCGTTGTATAGGTAGCTAACAGCTGCTCTTGTGTGAATAGCATTAGTGATCGAGTAGGATAAAAACACAATCCTAATTCGAAACAAGGAGACTTACGATACGTCATGTGATTTATGTTGTAGGACGGCAAACAGCTCTTCCCCTGAACTTGCCCCGCTGGAGAACGCTCACATCATGAAGTTCCTTTCAGAAAACATGTCCTTCAACCCCTCAAAGCCTAGCACTGACAGCTACACAACAGACAACTATGATAAGCAAGTCAACCTGAACAACATCTTCGACTCTCTCCTGCCTCAACC
GTC/TTAATTAAGCTGTTGTA GCAGAAATCATGGCAATCGGATCAAACCTTTCTGGAGGCCACACCTGAGGTCCGCATTTATGTAATACATTTTCCCAAGACACATTTACAATATACATTAATATAACAACATTCAAGTTTAGGTTATCTTTATATTAAATATTATTTTATGTCTTTTTAGTCATAGAAACTAATGTATTCTTAATTATTGTACTTACTTAATAATTATGATCAATTTGTGACACATCTGTTTGTTTACTTCACAAAAAACAGCATATTGGCCACAATGGATTTGGGGGACAGACAAGCCCTGTTTACTCAGATTCCTACTCTTCTCCAGGAAGATACAGGTAAGATTTTACAAATCGGTCAATTCTCATGCATTTTGCCTCTATAAAAATAACTATGTCACTTGGTGATCCTATGCAAGCCATAAAAAAAAATCAACACTGAGTAATGCTGTTGCATTAATATATTTGCATTTGAATGTTTTCGCAGGAATGATTTCCAATTCCTTCTCG - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
grhl3ltu1/ltu1 | Homozygous | ♀+/- ♂+/- | Figure 1 from Mathiyalagan et al., 2019 | ||
grhl3ltu1/ltu1 (TU) | Homozygous | ♀+/- ♂+/- | Fig. 1 from Miles et al., 2017 | Fig. 1 from Miles et al., 2017 |
1 - 2 of 2
Show
Supplemental Information
- Genotyping protocol
- None
- Mathiyalagan, N., Miles, L.B., Anderson, P.J., Wilanowski, T., Grills, B.L., McDonald, S.J., Keightley, M.C., Charzynska, A., Dabrowski, M., Dworkin, S. (2019) Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Genes. 10(11)
- Miles, L.B., Darido, C., Kaslin, J., Heath, J.K., Jane, S.M., Dworkin, S. (2017) Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension. Scientific Reports. 7:17607
1 - 2 of 2
Show