Genomic Feature
t26393
- ID
- ZDB-ALT-170119-17
- Name
- t26393
- Synonyms
-
- KL069 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 21: 36408843 (GRCz11) (1) Details
- Nucleotide change
- T/G
- Variant Notes
-
truncation occurs in WD repeat 8
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Tyr>Stop at position 437 (1)
- Flanking Sequence
-
TTGCATGTGTAAATTCCCCCAGCCTGGCCAGACTTGCATGGAGCCACGCACAAGGTTACAAAAAATGCCAGTTGAAATGATGTCATGCACACCCAAATTGAGCTTCCATCAACAGTATGATGATGTCACATTCACTGCATGTACCCAAGTGAACTTGCCGATGCTTCAAGTATAAACCAGTCTGAAGTCAAGCAGGCTGGAGAGTAATGATAGTGTGCTGGTGTAATTCTAGTTAAATTAAAATTCAGTTTAGTTTAGTATAAATGTCACTTAAAGTTCAGTTTAATTCAGACTACCAATTGACTGAACTGAACTCATCTATGACCATAACTAACATCTGCTCGGAATACGTGCCAGATCCAAGATTATGTGAACATCAGGATAAGGGTAAACAAGGTCATAAATGTAACTTTTTCCACACTTTTCTTACAGTTGGCATGGCATCCACTTAAAGAAGGCTCGCTGGCTTTTGGTACCGATGATGGTAAAGTTGGCATCTA
T/G GAGGTTTACTCGAACAGGTAAGAAAATATATATACCATTATGCTTCAATGATTTGCACTTACATATAAGAAATGTTGGAAGTTCTGCAAAAATACATTTGATATAATCTTCAATATTAGGGTTAAATGAAAATAAAACCATTATATGTTCACTCTCATGTTGTCACAAATTCATGGCATTCACTTATCTTCAGAGAACAAATGAAGGTATTTTAATTTAAAAAGAGATTCTTATTCTTCCCTTGATAGTCTGTGCTAGGGTTGGGCAATGTCTATTAATTTGGCATCGTACGATGTCTAATGTGAAACATCGCGATGGGCGATGGCATTGTCATCATGTGAAAATGACAGAGAGTCCGAAGGACTTGGGAAATCTGAATATCACGTTTAACAACTGTAGTGAGATGTGAAACAGCGGTACATCCTTGATAAACTGTCCGACATGCACTGCTCTCTGGAGCTCAGAGGAGCGCATGACAGTGTCTGTGTCTCCGTGTGTGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gemin5t26393/t26393 | Homozygous | ♀+/- ♂+/- | 4 figures  from Iwanami et al., 2016 | 3 figures from Iwanami et al., 2016 | |
| gemin5t26393/t26393; fr101Tg | Complex | Fig. 2 from Iwanami et al., 2016 | Fig. 2 from Iwanami et al., 2016 | ||
| gemin5t26393; lsm8fr100/fr100 | Complex | Fig. 3 from Iwanami et al., 2016 | |||
| gemin5t26393/t26393; lsm8fr100/fr100 | Complex | ||||
| gemin5t26393/t26393; lsm8fr100 | Complex | Fig. 3 from Iwanami et al., 2016 | |||
| gemin5t26393/t26393; lsm8fr100 | Complex | Fig. 3 from Iwanami et al., 2016 | |||
| gemin5t26393/t26393; tnpo3t22074/t22074 | Complex | Fig. 5 from Iwanami et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270
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