Genomic Feature
hu10535
- ID
- ZDB-ALT-160721-18
- Name
- hu10535
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Schulte-Merker
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 35432667 - 35432674 (GRCz11) (1) Details
- Nucleotide change
- CTGAAAAA/-
- Variant Notes
-
Frameshift at aa 5; additional 1 aa then stop.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- at position 5 (1)
- Flanking Sequence
-
CTGTTTACCGCACTCAATATCTTCGCTCCTAAAGCACAAGTAAACAGTTTTCTTGTGCTTTAGATTTTCCATAGACATCCCAACAATAATTAAAATACCATTATGAAGGTAAATAACAACACCAATACTTTAAATAACAATACAATTTTGTCAATAATAACAATACAATTACTGTAAGTCAATTTAAGTAAAACTGACGGGAACCAAAATGACAATAATTTAAAATGTAGGATAAAAAACCTTAACGTTTTCCTTTAATAAGGGAAATAATTGTCTAATAAAGGCCTATCCATAACGTGTAATAAACACTAGTCACTGCTTACGCCGTTCTAACGGTTTCATGATTGTCGTAAAATGAAAGTACACTCACCAGAGCCACTTCTTTGTCTGTGTGAGCAGTATCATCGCCGGGGAACTTTATGATGGGTGAGGGCGCAGCAAAAGTTTGCAGGGAAGCAAGAAACTGCACGAGGAAAACTTTAAGGACAATATGCCTACAG
CTGAAAAA/- CTTAACGGACATCATGCTGGTCCGATTCCGAGATGTCCGGGTATTGAAAATAGGGTGGCGAACAGCCCTTTCAGACGTGTTCACCAAGCTCCAAGTTTGTTCGACTGCACTGCAAATGCTCTTTCTTGTCCTCAGCGACACATCCTGCTTTCGTGGTCTGTGGAAAGGGTTCTGCTTGCACACGCACTTTCTTGATGCTGGGGCTGGAGAGGGACTGCGCAGCCTCCAGATCCAAGAATTTGGGAAAGCAGTGAAATAGGAGACGGCAGCGGGAGCGAGCAAGCTAGAGTTGTTTGTGCGCGCGCCCAATAGCACCGAACCTAAAGTTTCAAGTTTACTTTTTACACAGTTGAAGTGGGGTTGCTTACCCTTCATTATCATGTTTCATGTTCAACATTGGTTGCAGTTACCTTGGATTGATAGCCTATATAAAAATTGATTATTTATCAATAGTTTGGCAGTAGGCCTATATTTGCAAACTGTCTTACATATCCATATGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mmp2hu10535/hu10535; hu5333Tg; hu7135Tg | Complex | Fig. 3  from Kok et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Theodore, L.N., Hagedorn, E.J., Cortes, M., Natsuhara, K., Liu, S.Y., Perlin, J.R., Yang, S., Daily, M.L., Zon, L.I., North, T.E. (2017) Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 8(5):1226-1241
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
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