Genomic Feature
fu46
- ID
- ZDB-ALT-160412-2
- Name
- fu46
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Lecaudey Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| fu46 has an eight-nucleotide deletion in the third exon of amotl2a, resulting ... | ZFIN Staff |
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 6: 27993786 - 27993793 (GRCz11) (1) Details
- Nucleotide change
- CAGCATCC/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted in Exon 3 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GAGGAGCCGAACAGGACGACAGCATGTGGGATGCGAAACGAGAGCATGCACGCTCACTAAGTGAGCGTCTTTTGCAACTCTCACTAGAGAGAAATTGTGCCCATGACAATATTCCCATGAGCTCATCGCATAGTTATCCCCAACTCTCTAATAACCACTCTGATACAGTTGTGAATGAGCAGTCAGTTCATCAGCCAGACCAACGGGGTCCTCCCCCGGAGTACCCCTTCATGGTCAGATCCCCTGGATATATGCTTAGTCATTCACAGGAACATGGACACTATTATAATGAGCCCCCTCCTGCCTTCCATTCACAGCATTACAGGTAAAATTATATTTTGGTCACATTGTATATACTGTACACTCTATATGAACATCATGGGTGTTCTAATGTTTATTTTTGTCTCTCTCAGGTTATTTCCAACACAGCCACAAGCACCTCGTCACAATGGCCTGCCCACATTGACCCCTGCTGGCCAGGATGTCAATGTTGGAGGATA
CAGCATCC/- CAGCGAACAACTTCCAAATGGAGCAGCTTATTAAAGAGAACGAAAGACTGAAAAGAGAAGTGGACAGCTACAGTGAGAAGGCGGCAAGGTTACAGAAGGTAACAGGATTCTTTGTGTGATTGCAACTTCCTTGCAACCTTCTAGAACTGTGATGTTTTTGGTATGACCTCACATTTTGCCATGGATGCAAAAAGGCAGCTGTGTCCTTTGATTGTGAACTCAGACATGACCTACAAAGAGTGAGAACAAGAAATCATTGTGCGCTGGTGTCTTCTAGCCTCTGCATTCTAAGAAGATTAGCTCTCTTGCCGTGTAGGAATGCATGCAAGGGAGAGGATCACAAGGACTTCAATTTAATTTGAAAAGGACACATTCTTGGTCACTGAGTGAAAATTCCCAGTAACTTATTTAGCATGCGAAACAACACTGAATTTACCCATGCCTAAAATGCCATGCATTTTTCTGTAATGTGATAATGTCATCACTGAAATACCAGAGTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| amotl2afu46/fu46; zf106Tg | Complex | 3 figures  from Agarwala et al., 2015 | 3 figures from Agarwala et al., 2015 | ||
| amotl2afu46/fu46; zf106Tg | Complex | Fig. 4 from Agarwala et al., 2015 | Fig. 4 from Agarwala et al., 2015 | ||
| amotl2afu46/fu46; zf106Tg + MO3-lef1 | Complex | Fig. 7 from Agarwala et al., 2015 | Fig. 7 from Agarwala et al., 2015 | ||
| amotl2afu46/fu46; yap1fu48/fu48; zf106Tg | Complex | Fig. 6, S1 from Agarwala et al., 2015 | 2 figures from Agarwala et al., 2015 | ||
| amotl2afu46/fu46; yap1fu48/fu48; zf106Tg + MO3-lef1 | Complex | Fig. 7 from Agarwala et al., 2015 | Fig. 7 from Agarwala et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Peralta, M., Ortiz Lopez, L., Jerabkova, K., Lucchesi, T., Vitre, B., Han, D., Guillemot, L., Dingare, C., Sumara, I., Mercader, N., Lecaudey, V., Delaval, B., Meilhac, S.M., Vermot, J. (2020) Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis. Cell Reports. 32:107932
- Agarwala, S., Duquesne, S., Liu, K., Boehm, A., Grimm, L., Link, S., König, S., Eimer, S., Ronneberger, O., Lecaudey, V. (2015) Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. eLIFE. 4:e08201
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