Genomic Feature
ibl31
- ID
- ZDB-ALT-120611-1
- Name
- ibl31
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- zinc finger nuclease
- Lab of Origin
- Haramis Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| rnf2 knockout was generated using zinc finger nuclease. This mutation ... | ZFIN Staff |
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 2: 23357622 - 23357635 (GRCz11) (1) Details
- Nucleotide change
- CCACAGTATCGAAG/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 14 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
ATATATCATACAACAAAAATATTTTATTTCCTGAAAATGTTGTCTTGTACACAGCCTTATAGCATAAATGTCTGTCAAAAGAAGCTAGTAGAGGGTTTTGACCAGTAACTAAATAAAACTATTCCTTATCACAACTAAATAAATGGACAAAAAAAGAAAGATTTATCCAGTTCCTATTACTAAAAATATAATCCCATCCTTCATTTTCACATTTGAGGTGATACGGATACACTTTACAATAGGGAACCATTTCTGTTTCATGTCTATTTTAGGCTGTTTATTTGTATTTTCATTGCCTAATTGTCATATCTCCTGTGTTCTTTCAGGAATAAGGAGTGTCCAACATGCAGAAAGAAGCTGGTGTCTAAGCGCTCTCTTCGTCCAGACCCTAACTTTGACGCTCTGATCAGTAAGATCTACCCCAGCAGAGACGAATACGAAGCCCACCAGGAGAGAGTGCTGGCCCGCATCAGCAAACACAACAACCAGCAGGCGCTCAG
CCACAGTATCGAAG/- AAGGCCTAAAAATCCAGGCCATGAACAGGTTTGCTGTTTAATATGAGCCATTTTGTCACAACCAATTTATATTTGTAGAATCAAAAATGTAGGTAATTTTTTTTAGTTTGCGGCTTTGTTACAAATCCTCTTGTTTACTGTTAACATGATAAAAATAGCTTCTTATTAATGTATAATCATCTTTTAACAGTTTACTGACTGCTCTGAGGCAGCTTTCTTTTAAGTGTAAAATGTGAATTTTGCACTTATTTTTTTATTTCTTCATCCTGTTTTGTTCCTGGGTTTACACCAATTCTCCACCGGGGCACTGTAGACTGCAGCGGGGGAAGAAGCATCAAATTGAAAACGGCAGCGGGGCAGAGGACAATGGGGACAGTTCACATTGCAGCAATGCATCAGTGCACAGTAACCAAGAGGCTGGACCCAGCATCAAACGAACCAAAACCTCAGATGACTCTGGACTGGACATGGACAATGCCACTGAGAATGGAGGAGGAGAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rnf2ibl31/ibl31 | Homozygous | ♀+/- ♂+/- | 11 figures  from 2 publications | 15 figures from 2 publications | |
| rnf2ibl31/ibl31 (TL) | Homozygous | ♀+/- ♂+/- | 2 figures from Chrispijn et al., 2019 | 2 figures from Chrispijn et al., 2019 | |
| rnf2ibl31/+ (AB) | Heterozygous | Unknown | |||
| rnf2ibl31/ibl31; twu34Tg (TL) | Complex | Figure 4 from Chrispijn et al., 2019 | Figure 4 from Chrispijn et al., 2019 | ||
| apchu745/hu745; rnf2ibl31/ibl31 | Complex | Fig. 8 from van der Velden et al., 2012 | Fig. 8 from van der Velden et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Chrispijn, N.D., Elurbe, D.M., Mickoleit, M., Aben, M., de Bakker, D.E.M., Andralojc, K.M., Huisken, J., Bakkers, J., Kamminga, L.M. (2019) Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development. Scientific Reports. 9:4327
- van der Velden, Y.U., Wang, L., Querol Cano, L., and Haramis, A.P. (2013) The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development. PLoS One. 8(9):e73997
- van der Velden, Y.U., Wang, L., van Lohuizen, M., and Haramis, A.P. (2012) The Polycomb group protein Ring1b is essential for pectoral fin development. Development (Cambridge, England). 139(12):2210-2220
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