Genomic Feature
sa1503
- ID
- ZDB-ALT-120411-187
- Name
- sa1503
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| This nonsense mutation results into the synthesis of a truncated protein that ... | Ferrero et al., 2020 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 21: 43867354 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A at Splice Junction (1)
- Transcript Consequence
- Splice Site, Premature Stop (2)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CTATGTGCATAATAGTAAAAATAACTTTAGTGAACTTAATAGTTTTAAGTTACAACGGATATACTTAAAAATTTTAAGTTAAATGAACCTAAAATTAGGTTTACTCACTTTATAAGTAGTTGCTTAATTTCCTATTTTGCTTTTGAAATGGACCTGTCTTAATGAAGCACCTTAAATGTGTTCATAAGGTCCTCGCCCTACATCGGTGTGGTCAACTTCAGTGCTAATCAGTCTTGGTCTCTCTGGAGCTCTCTCTGTGGCAACTCTATGGATGTTAATTCTCCTCTACAAGAACAGAAAGGTATCTTTTATTTACCTGAGTTATACTCACAATCATGCAAATTTAACAGTTTGTTTAACCTGATACTTTAAGGCACAGAAGTATGAGATTCAATGGAAAATCATTGAGGTAAATGATGGGAACAACTACACATTCATTGACCCCAGCCAACTTCCATACAACAAGAAACTGGAGTTTCCTCGAAATAAGCTGAAGCTTG
G/A TACTTACACTCTCTGTTTTACTAGAGTATAATTTTGTAATGATAAGAAATAACTACTGCAAAAAAAAACAATGCTTGCACTCCAGGACAGGTTCTTGGAGCAGGAGCGTTTGGGAAGGTGGTGCAAGCAACTGCTATTGGCCTGGTCAAGGATGAAACCATCACACGAGTGGCGGTGAAAATGCTCAAGCGTAAGTTTAATTTAATTATGGCTTTTAAAATTTTTTAAATAATTTTTTATAATTATTTTTAGGGGTTTTCAACTTTAATGTGATAGGACAGTAAAGGACAGTCAGGAAAGCATTAGGAGCAGAGAGAGGGGAAGGATCGGCATAGGACCCTGAGCCGGGAATCAAACTTAGGTCACCGTGAGCACCTTGGGCCTATATGTTAACGCACTAGGCCTCTAGGCTACGCTATTGGCGCAGATGACACTAGAAATTGTTAACCCTGGGCATCCTAAACCCATGGATAAATGGAACCTGTGTCATCTGTGTCATG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| csf1rbsa1503/sa1503 | Homozygous | ♀+/- ♂+/- | text only from Ferrero et al., 2020 | ||
| csf1rbsa1503/sa1503 (TL) | Homozygous | ♀+/- ♂+/- | text only from Busch-Nentwich et al., 2012 | ||
| csf1raj4e1/j4e1; csf1rbsa1503/sa1503 | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Rovira, M., Miserocchi, M., Montanari, A., Hammou, L., Chomette, L., Pozo, J., Imbault, V., Bisteau, X., Wittamer, V. (2022) Zebrafish Galectin 3 binding protein (Lgals3bp) is the target antigen of the microglial 4C4 monoclonal antibody. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):400-414
- Ferrero, G., Miserocchi, M., Di Ruggiero, E., Wittamer, V. (2020) A csf1rb mutation uncouples two waves of microglia development in zebrafish. Development (Cambridge, England). 148(1):
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
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