Genomic Feature
hu3264
- ID
- ZDB-ALT-080814-9
- Name
- hu3264
- Synonyms
-
- huW671X (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 51437401 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Trp>Stop at position 671 (1)
- Flanking Sequence
-
GCACTTTGGTGACTGTCGCTTTAAATTCAAATGAGATTGTGCTGTATTTAAATAAGGGCGGAGCTACAAGTGCCTGTGTGTCAGCATAGCGGCAGATTCAAAGACTAGACAAACGTCCTATGCTAATGAGGGAGAGATAGTCACTAGTGGGCGGGGCTTTCCCCCTCTGATGACACGTACAACTGGAGAATGTCAATCAAAGTGTTTCTGCAGACTGTTTATATCAAGTGTGATTTAAAAAAAATAATTAATACATTTTTACAATTAGAGACTGGATATATTCACACACTCTCACCACACAACTACATTTAAACCCTTTATAAAAGTGATTTTTTCATAATAGGTGCCCTTTAAAACTAGTCTTACAGCTCATGTGTGCATGTGGAGGGTCGGTCCATGCGGTGTCCTTCCTTCAGCAGCTTAAAGAGCTCCTCGACGGGGACGCCGGGGTACGGAGAGCCCCCCAGAGTGAAGATCTCCCACAGCAGCACCCCAAAAGA
C/T CAGCTGAGGTCATCAACACACAAGAGTTATTACTTATGAAAGCACAGTGTATTTGAGAGATTTGCAGAGAATGTGCGTTTACACGTACACGTCACTTTGATGGGTGTATATGCGGTCAAACAGAGCTTCGGGAGCCATCCATTTCACCGGCAAACGACCCTGAAAAAAACACAACACTCAATAACTCATAATCAAAAACAGAACTAATATCTGCTTTGAAAAATGAAGCGATCAAAACCTGCTGGGATGAAAGTACATATGCTGTAAATATACACTCACTGGCCACTTTATTAGGTACACCTGTCTAACTGCTTGTTAACTCAAATTTCGGTGTAATGGCTTTATCCCTTTATGACCGCAGTGTACACATCTTCTGATGGCTACTTCCAACAGGATAACGCGCCATGTCATAAAGTGTGAATCCTCTCAGACTGGTTTCATGAACATGGCAATGAGTTCACTGTACTCAAATGGCCTCCACAGTCACCATATCTCAGTCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| fgfr1ahu3264/hu3264 | Homozygous | ♀-/- ♂-/- | Fig. S6  from Rohner et al., 2009 | Fig. S6 from Rohner et al., 2009 | |
| fgfr1ahu3264/hu3264 | Homozygous | ♀+/- ♂+/- | |||
| fgfr1ahu3264 | Unknown | Unknown | |||
| fgfr1ahu3264/+; fgfr1at2227/+ | Complex | Fig. 2 from Rohner et al., 2009 | |||
| fgfr1ahu3264/+; fgfr1at2227/+ | Complex | ||||
| fgfr1ahu3264/hu3264 + MO1-fgfr1b | Complex | Fig. S6 from Rohner et al., 2009 | Fig. S6 from Rohner et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- Norton, W.H., Stumpenhorst, K., Faus-Kessler, T., Folchert, A., Rohner, N., Harris, M.P., Callebert, J., and Bally-Cuif, L. (2011) Modulation of Fgfr1a Signaling in Zebrafish Reveals a Genetic Basis for the Aggression-Boldness Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(39):13796-13807
- Rohner, N., Bercsényi, M., Orbán, L., Kolanczyk, M.E., Linke, D., Brand, M., Nüsslein-Volhard, C., and Harris, M.P. (2009) Duplication of fgfr1 Permits Fgf Signaling to Serve as a Target for Selection during Domestication. Current biology : CB. 19(19):1642-1647
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