Genomic Feature
a69
- ID
- ZDB-ALT-061106-2
- Name
- a69
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Dowling Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 41700184 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Ser at position 56 (1)
- Flanking Sequence
-
AGTTCAGGACAATTGATGTCTGCTTTTGTCAGTTGTTCGAGACGTGGTCATGAATGGCGGCACACAGACATGTGGGAGGATGGATGAGGGTCTCGCTTCAAAGATAGAAGGAGAAACTGGAGATCTAAAGCCCTGGTGTTGACCTTATCCTGCAACTCTTAAGTGCTCTCAATTTTGCATTTGCTTTAGAATTTCAGATTCAGCTCGCTATGGAGGAAATGATTAGGAATGATAAACAGCAGGAATCAACAACTTGCTCTACAAACAAGTGTGTTCACGACTAAACATAGGAAGCTGAATAGGAAGTTCTAAAACAAACGCAAAAACGAGCGCACTTACGAGTTGCAGGAGAAGCTCAATACTGATGCCTTTATCATTGATTAGAGTCGTTAAATATCCTCCATCTGTCCTCAGGTTTGTTTCCTGCAATCTTGAATCTCGCCAGCAATGCCGAAATCAGCACCAACGCCACCTGTGGCGATCCCGATCCCGAGATGTTC
T/A GCAAACTGGTGGAGCACGTTCCTGGAAGACGGATCCGCAACCCGCAGTGTCGCATCTGTGACGCAAACAGCCAGAATCCCAAAGGTAAATCAGGCGTGTTCACTTTGTTCAGTTAACCCTTGTGTGCTGTTCGATTTGGTGATGTTGGTGCTGTTTTTGCCCCATTGACTTCCATTATAGTCACATTTATTGACTGCAAAGTCCATGACTGCATATAATCATGCATTACTGACTGCTGCTGGTTTTCTCTTTTGGGATTGAGAGGGACGATGTGTAATTTTACCTGTTAACCACTTAAACTCTGCGGACCCGGTACCGGATCTGTGACGTCATCGGCTTTCGCTTTCAGATTTAAAGGGCTAGCGTTGCACCAGACCCCTGTGGTGTCGTTTGAAAGTGTAGAATCTATATTTTATGCACATATGCATCACTTTGGTTTTTATTTTACTGTATAAATGTTATTTACACTTAAATGCACAGTATTTTGGAGACCCGAGCTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lama1a69/a69 | Homozygous | Unknown | Fig. for (a69) from Phenotype Annotation (1994-2006) | Fig. 5  from Semina et al., 2006 | |
| lama1a69/a69 | Homozygous | ♀+/- ♂+/- | 3 figures from Pathania et al., 2014 |
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Supplemental Information
- Genotyping protocol
- None
- Pathania, M., Semina, E.V., and Duncan, M.K. (2014) Lens extrusion from Laminin alpha 1 mutant zebrafish. TheScientificWorldJournal. 2014:524929
- Paulus, J.D., and Halloran, M.C. (2006) Zebrafish bashful/laminin-alpha1 mutants exhibit multiple axon guidance defects. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(1):213-224
- Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A. (2006) Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Developmental Biology. 299(1):63-77
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