Genomic Feature
uw1
- ID
- ZDB-ALT-060117-2
- Name
- uw1
- Synonyms
-
- bashful (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Halloran Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 41746380 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Splice Site (1)
- Protein Consequence
- None
- Flanking Sequence
-
TCAAACTAGTGACCTTCTTGCTGTGAGGCGATTGTGCTAACCACTGCGCCACCGTGATGCCTGCATCATCAAAATAGTCAGCATTATCGGTCATCATGGCGTACATGCAGACTCATCACCTGCTCAAACTGCACCTGAGACTGGTGTACATATGAAATATACCCAGCACACACCAGATATCAACATGATGTCAGACTGATGTTGTACTCCGACATTGTGGGATGTTGCATTGTGTTTGCTTTATTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATTATTACACTTATTTATGTGATGTTTTTACCCATCATGCTTTGTGTTGCAGGAGTGTGCTCCAGGATATTACCGGCAGGCTGTATCTGAGCTCAACATGAAGGGCAGAAATCGGCCGCTCATTCAGCCCTGTGTGCCCTGCAGATGCAGCAACCACAGCCAGTCATGTGACCTGCACACCGGCCAATGCCTG
G/A TGAGAACACACACACACAGACACACACACTTTGAAGTGCACCTATTATGCAAAACCCACTTTTATATGTGGTTTAACCCCAGCTGTGTGTCAGCAGTGTGTGAGTATCTCCAGCAGCCTCTGATGCTCAACATGTATTAATTGTGTTTGTTCTAATCAGACTTGATGAGTGAAGCACTTTGATTGACATTCTCCCTTTGTACGTGTCATCAGAGGGGGAAAGCCCCGCCCACTAGTGCCCCTCTCTCCATGTCATTAGCATAAACAGCAGCCCTGAGTGAGAAGCAGCCGTCTGTCCATTAGCCATTAGAGTGTTTGAGCTGCTGAAGATGATGTCAGCATAGACTAAGAGCATTATAGATGTGGAGTTCTAGATGAACAGAGACAGGAGCGACAGAGACTGACAGAAGCATGAAGAACACACTGAAGCACACCTGACCAGCACTCACAACACACACACTGCTGATTTACATGTCACTATGCTTATGCATATGCATCTGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lama1uw1/uw1 | Homozygous | ♀+/- ♂+/- | 7 figures  from 3 publications | Fig. 7 from Sittaramane et al., 2009 | |
| lama1uw1/uw1 (AB) | Homozygous | ♀+/- ♂+/- | |||
| lama1uw1 | Unknown | Unknown | Fig. for (uw1) from Phenotype Annotation (1994-2006) | 2 figures from Paulus et al., 2006 | |
| lama1uw1/uw1; zy8Tg | Complex | 4 figures from Wolman et al., 2008 | 4 figures from Wolman et al., 2008 | ||
| lama1uw1/+ + MO1-cntn2 | Complex | Fig. 7 from Sittaramane et al., 2009 | Fig. 7 from Sittaramane et al., 2009 | ||
| lama1uw1/uw1; pard3abfh305/fh305 | Complex | Fig. 5 from Carney et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Falat, E.J., Voit, G.C., Gutzman, J.H. (2022) Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding. Developmental Biology. 492:172-186
- Carney, K.R., Bryan, C.D., Gordon, H.B., Kwan, K.M. (2020) LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation. Developmental Biology. 458:1-11
- Bryan, C.D., Chien, C.B., Kwan, K.M. (2016) Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis. Developmental Biology. 416(2):324-37
- Andersen, E.F., and Halloran, M.C. (2012) Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity. Development (Cambridge, England). 139(19):3590-3599
- Grant, P.K., and Moens, C.B. (2010) The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrain. Neural Development. 5:9
- Paulus, J.D., Willer, G.B., Willer, J.R., Gregg, R.G., and Halloran, M.C. (2009) Muscle contractions guide Rohon-Beard peripheral sensory axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(42):13190-13201
- Sittaramane, V., Sawant, A., Wolman, M.A., Maves, L., Halloran, M.C., and Chandrasekhar, A. (2009) The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininalpha1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Developmental Biology. 325(2):363-373
- Wolman, M.A., Sittaramane, V., Essner, J.J., Yost, H.J., Chandrasekhar, A., and Halloran, M.C. (2008) Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo. Neural Development. 3:6
- Paulus, J.D., and Halloran, M.C. (2006) Zebrafish bashful/laminin-alpha1 mutants exhibit multiple axon guidance defects. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(1):213-224
- Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A. (2006) Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Developmental Biology. 299(1):63-77
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