Genomic Feature
c14
- ID
- ZDB-ALT-030731-2
- Name
- c14
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Halpern Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 16: 46423302 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
-
This is a T269A mutation.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A at position 269 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Val>Glu at position 90 (1)
- Flanking Sequence
-
GGACAGTTTTTTTTTTTTTTTTTGAGGAATTTGCTTGCTTTGACACATTATTTAAAACAAAAAATTTTTTCGGAAAGAAAATGAGATGAGAAATGCTGATTAAAAGCTTAACTTGTACTGAACCCTAAATGATTCAGTAGCACTGATACTTTATATTTTCAACAGAAATTCTGTTTAAGATTGTGGTCTGTTTCCCTCTTCAGGTGAACCATCAGATCTTCCACCGGACACAATGGCCGACAATGAATTATTCGATGACCCCGAGAAGCTGAAGCGGGGTCTGGTGAAGGTGCTAGAATGTGTGGCCACCATCTCCTCAGCAGCAGCGGTGGTCAATCCCATCTTCGGTGTGGCTGGATCTCTCATCCGTGTGGTTCTACACCACGTGGACGATGAAGACCTCCAGAAACTCAAGCGAGAGTTCGGCAGCGTCAATCGAGCTCTGGATGAAATTTCACAGCAAAACCGCCAAGCCCTGCTTCAAATACGGAAGGAAACTG
T/A GGACAGACAGTACCACGAAGTGGAGGAAAACATCCGCCATCAGTTCCGCAAGTTCATGGAGATCATGGAGGCAAAGCCGGAGCATCTCCAACGCAAGAAGGAGGATTTCGTGGAGAGCTTCATCAATGATAAAGACGACCAGAACATGTACACGCTTTACGACGGTGTGATGGGGAAGCGCAAGCTCTTCAGTCAGCCAATATTAGATGTGTACATGAAGCACTCACAAGGAGATCACCGTGTCATGGAAAACCTCTGCACTCGACTGGCGTACCTCTTCTGCATCGGTTTCATCGCTCTCATGGGCTACTACGGCATCCTGGGAGATGATCTGGAGTCTCGAAATGAGGAGTGGGAGGAAAACATGAGGAATGTGCAGGAGAAAATGCAGGAGGTGCTCAGGAGTTGCAAGTGATGCACAAACGACGCTCTTTATTGCCTTTTTCCTCTAATAGACTTCATTGATCTGCAGTGTCTAATGCAGCATTATCCTCCCGATG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rpzc14/c14 | Homozygous | Unknown | |||
| rpzc14/c14 | Homozygous | ♀+/- ♂+/- | 2 figures  from Green et al., 2009 | Fig. 4 from Green et al., 2009 | |
| rpzc14/+ | Heterozygous | ♀+/- ♂+/- | Fig. 6 from Green et al., 2009 | 2 figures from Green et al., 2009 | |
| rpzc14/+ (AB) | Heterozygous | Unknown | |||
| rpzc14/+ (SJA) | Heterozygous | Unknown | |||
| rpzc14 | Unknown | Unknown | Fig. for (c14) from Phenotype Annotation (1994-2006) | ||
| rpzc14/c14 + MO1-rpz | Complex | Fig. 3 from Green et al., 2009 | |||
| rpzc14/c14 + MO1-rpz2 | Complex | Fig. 3 from Green et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- Green, J., Taylor, J.J., Hindes, A., Johnson, S.L., and Goldsmith, M.I. (2009) A gain of function mutation causing skeletal overgrowth in the rapunzel mutant. Developmental Biology. 334(1):224-234
- Yang, C.T., Hindes, A.E., Hultman, K.A., and Johnson, S.L. (2007) Mutations in gfpt1 and skiv2l2 Cause Distinct Stage-Specific Defects in Larval Melanocyte Regeneration in Zebrafish. PLoS Genetics. 3(6):e88
- Goldsmith, M.I., Fisher, S., Waterman, R., and Johnson, S.L. (2003) Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants. Developmental Biology. 259(2):303-317
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