Genomic Feature
hi10Tg
- ID
- ZDB-ALT-020422-4
- Name
- hi10Tg
- Synonyms
-
- hi10 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 5: 22511833 - 22511834 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 3 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rpl36ahi10Tg/hi10Tg | Homozygous | ♀+/- ♂+/- | 2 figures from Amsterdam et al., 1999 | ||
| rpl36ahi10Tg/hi10Tg | Homozygous | Unknown | text only from Amsterdam et al., 2004 | ||
| rpl36ahi10Tg/+ | Heterozygous | Unknown | Fig. 2  from Zhang et al., 2010 | ||
| rpl36ahi10Tg/+ (AB) | Heterozygous | Unknown | |||
| rpl36ahi10Tg/+ (AB/TU) | Heterozygous | Unknown | Fig. 3 from Lai et al., 2009 | ||
| rpl36ahi10Tg | Unknown | Unknown | Fig. for (hi10) from Phenotype Annotation (1994-2006) | ||
| nf2bhi3332Tg/+; rpl36ahi10Tg/+ | Complex | ||||
| rpl36ahi10Tg/+; tln1hi3093Tg/+ | Complex |
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Supplemental Information
- Genotyping protocol
- hi10tg.pdf
- Antunes, A.T., Goos, Y.J., Pereboom, T.C., Hermkens, D., Wlodarski, M.W., Da Costa, L., MacInnes, A.W. (2015) Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway. PLoS Genetics. 11:e1005326
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A., and Hopkins, N. (2010) Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107(39):16940-16945
- Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):76-85
- MacInnes, A.W., Amsterdam, A., Whittaker, C.A., Hopkins, N., and Lees, J.A. (2008) Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proceedings of the National Academy of Sciences of the United States of America. 105(30):10408-10413
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S., Bronson, R.T., Lees, J.A., and Hopkins, N. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biology. 2(5):E139
- Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes & Development. 13(20):2713-2724
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