Genomic Feature
s9
- ID
- ZDB-ALT-000621-2
- Name
- s9
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 43717424 (GRCz11) (1) Details
- Nucleotide change
- A/G
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Val>Ala at position 104 (1)
- Flanking Sequence
-
ACATCATGAAGTTACTCTGAGATGGCAGAGGAGGAATGACCACCTTCATCTCCGGCCCGATGGTCTTGTTAGGAGGGAAGTTGTCATACTCCACCAAAAACTGCTTCATTGTTGATTTAGCGTGGTTTGCTGAATGTGTGAACTGTTCGTGTTCCTTTGGGTACTGCTGTGTGTAACTGCGCGGCACCACCACACTCAGGTGATCAGTTTTGATGGGATTCTCCTGGGTTCTGCTGAACATGCATGGGATGGTGGTTGGGTCGTATATGTCACCTTTAATGGTGCTGATTTTCTCCTCTGAAGAGTTGATGAGCTGCTGATGGAAGCTGTCTGCTGTAAATGTTGAGGTTCTTTGTAAGTTCTCCAGGCCGCTGTGGTTCTGATGTGTGGTAAACTGGTGCATAAGGAGATTGTTGGGGGTCAGGATGTTTCCGCTCGTCTTGTTTGGGATTGAAATTCCCACCTGGCGCCGAGACTTCGCCCTTCGGTTCTGGAACCAG
A/G CCTGAAGAGAAGATGGAGACATTAATTTAGGAATGTGAGGCCATTTGAATGAAATCTATAACATTCTTAGCACAAACATTTAGACAAAGATAGCTGCAGAAATGATCAGAGCTGCTTATTTGAATGGTTTAGTATTTGTTTTTACCATCAGAGTGGACCATAAAACCTACAAACCTTTATTTCTACATCACATGAAAGCTGAATAAATAAGAAGTCCACTGACATATGTTTCGTTAAGTTTGAACAATTGAACAATATTTGGATTGAGGTTAAAAAAATAAAAATAAATATAAAATCGAAATATTGAAGAAAATCACCTTTAAAGTTGATTATATTATAAATTAAAGTTAAACTAAATTATGATATTTATATCAAGACATTCAGTAAAAGGGGAAAATATTGTGAGACTGATAACAGCAGCCAGAAGAGAGAAAAACGTCAAATTTACTGTCCTGTCCTACAGATGCTACATTAGAAACATCTCGCTAAAGCAGTAATTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mixl1s9/s9 | Homozygous | Unknown | Fig. for (s9) from Phenotype Annotation (1994-2006) | text only from Kunwar et al., 2003 | |
| mixl1s9/s9 | Homozygous | ♀+/- ♂+/- | 2 figures from Kikuchi et al., 2000 | Fig. 2 from Kikuchi et al., 2000 |
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Supplemental Information
- Genotyping protocol
- None
- Elsalini, O.A., Gartzen, J., Cramer, M., and Rohr, K.B. (2003) Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors. Developmental Biology. 263(1):67-80
- Kunwar, P.S., Zimmerman, S., Bennett, J.T., Chen, Y., Whitman, M., and Schier, A.F. (2003) Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction. Development (Cambridge, England). 130(23):5589-5599
- Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B., and Stainier, D.Y. (2001) casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development. 15(12):1493-1505
- Kikuchi, Y., Trinh, L.A., Reiter, J.F., Alexander, J., Yelon, D., and Stainier, D.Y.R. (2000) The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes & Development. 14(10):1279-1289
- Alexander, J., Stainier, D.Y.R., and Yelon, D. (1998) Screening mosaic F1 females for mutations affecting zebrafish heart induction and patterning. Developmental genetics. 22:288-299
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