| ZFIN ID: ZDB-EXP-240516-2 |
Experiment Conditions Description: cold damage: cardiac ventricle, chemical treatment by environment: mocetinostat
| cold damage: cardiac ventricle |
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| Name: | cold damage |
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| Synonyms: | |
| Definition: | Physical alteration which uses cold to damage an anatomical structure, cell, or organ |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000248] |
| Name: | cardiac ventricle |
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| Synonyms: | ventricle |
| Definition: | Cavitated compound organ that receives blood flow from the atrium and delivers blood to the body via the aorta. Valves are present to direct flow. There are only two chambers present in the fish heart. |
| Ontology: | Anatomy Ontology [ZFA:0000009] |
| chemical treatment by environment: mocetinostat |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | mocetinostat |
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| Synonyms: | MG 0103, MGCD 0103, MGCD-0103, MGCD0103, mocetinostat, mocetinostatum, N-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide |
| Definition: | A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11). |
| Ontology: | ChEBI [CHEBI:197437] ( EBI ) |
| Publication: | Bühler et al., 2021 |
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