ZFIN ID: ZDB-EXP-240221-2
Experiment Conditions Description: chemical treatment by environment: biliatresone, chemical treatment by environment: tanespimycin, chemical treatment by environment: N-acetyl-L-cysteine
chemical treatment by environment: biliatresone
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: biliatresone
Synonyms: 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)prop-2-en-1-one, 2-[2-(2-hydroxyphenyl)-3-oxoprop-1-en-3-yl]-1,3-dimethoxy-4,5-methylenedioxybenzene
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted at positions 5 by a 2-(2-hydroxyphenyl)-3-oxoprop-1-en-3-yl group and at positions 4 and 6 by methoxy groups. A very rare type of isoflavonoid-related 1,2-diaryl-2-propenone found in Dysphania glomulifera (red crumbweed) and D. littoralis, the enone moiety is particularly reactive, undergoing ready Michael addition of water and methanol. Biliatresone has been found to cause extrahepatic biliary atresia (obliteration or discontinuity of the extrahepatic biliary system, resulting in obstruction to bile flow) in a zebrafish model.
Ontology: ChEBI [CHEBI:131631]  ( EBI )
chemical treatment by environment: tanespimycin
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: tanespimycin
Synonyms: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, 17-AAG, 17-allylaminogeldanamycin, 17-demethoxy-17-(2-propenylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-N-allylamino-17-demethoxygeldanamycin, 17AAG, NSC 330507, NSC-330507, tanespimycin, tanespimycina, tanespimycine, tanespimycinum
Definition: A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Ontology: ChEBI [CHEBI:64153]  ( EBI )
chemical treatment by environment: N-acetyl-L-cysteine
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: N-acetyl-L-cysteine
Synonyms: (2R)-2-acetylamino-3-sulfanylpropanoic acid, (R)-2-acetylamino-3-mercaptopropanoic acid, (R)-mercapturic acid, acetilcisteina, Acetylcysteine, acetylcysteinum, L-acetylcysteine, L-alpha-acetamido-beta-mercaptopropionic acid, mercapturic acid, N-acetyl-L-(+)-cysteine, N-acetyl-L-cysteine, N-acetylcysteine, NAC
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Ontology: ChEBI [CHEBI:28939]  ( EBI )
Publication: Zhao et al., 2020