| ZFIN ID: ZDB-EXP-220215-6 |
Experiment Conditions Description: chemical treatment by gavage: diacetylmonoxime, chemical treatment by environment: metronidazole
| chemical treatment by gavage: diacetylmonoxime |
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| Name: | chemical treatment by gavage |
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| Synonyms: | |
| Definition: | Chemical treatment condition where the chemical is introduced to the organism by gavage. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000255] |
| Name: | diacetylmonoxime |
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| Synonyms: | 2,3-butadione monooxime, 2,3-butanedione 3-monoxime, 2,3-butanedione monoxime, 2,3-butanedione oxime, 2,3-butanedione-2-monoxime, 2-hydroxyimino-3-butanone, 2-oximino-3-butanone, 3-(hydroxyimino)-2-butanone, 3-(hydroxyimino)butan-2-one, 3-oximino-2-butanone, 3-oxo-2-butanone oxime, biacetyl monooxime, biacetyl monoxime, DAM, DAM (oxime), diacetyl monooxime, diacetyl monoxime, diacetylmonoxime, isonitrosoethyl methyl ketone |
| Definition: | A ketoxime obtained via formal condensation of butane-2,3-dione with hydroxylamine. It is a reversible myosin ATPase inhibitor. |
| Ontology: | ChEBI [CHEBI:4480] ( EBI ) |
| chemical treatment by environment: metronidazole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | metronidazole |
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| Synonyms: | 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum |
| Definition: | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
| Ontology: | ChEBI [CHEBI:6909] ( EBI ) |
| Publication: | Li et al., 2020 |
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