ZFIN ID: ZDB-EXP-220122-5
Experiment Conditions Description: chemical treatment by environment: aristolochic acid A
chemical treatment by environment: aristolochic acid A
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: aristolochic acid A
Synonyms: 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid, 8-methoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, 8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, Aristolochic acid, aristolochic acid A, Aristolochic acid I, aristolochic acid-I, aristolochin
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Ontology: ChEBI [CHEBI:2825]  ( EBI )
Publication: Haege et al., 2021