| ZFIN ID: ZDB-EXP-201015-9 |
Experiment Conditions Description: chemical treatment by environment: D-cycloserine
| chemical treatment by environment: D-cycloserine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | D-cycloserine |
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| Synonyms: | (+)-4-amino-3-isoxazolidinone, (+)-cycloserine, (4R)-4-aminoisoxazolidin-3-one, (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, alpha-Cycloserine, cicloserina, cyclo-D-serine, cycloserine, cycloserinum, D-(+)-cycloserine, D-4-amino-3-isoxazolidinone, D-4-amino-3-isoxazolidone, D-Cycloserine, DCS, orientomycin, PA 94, PA-94, Ro-1-9213, Seromycin |
| Definition: | A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). |
| Ontology: | ChEBI [CHEBI:40009] ( EBI ) |
| Publication: | Liu et al., 2019 |
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