| ZFIN ID: ZDB-EXP-200604-5 |
Experiment Conditions Description: chemical ablation: neutrophil, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor, chemical treatment by environment: metronidazole
| chemical ablation: neutrophil |
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| Name: | chemical ablation |
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| Synonyms: | |
| Definition: | Experimental condition which uses a chemical to ablate an anatomical structure or cell. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000169] |
| Name: | neutrophil |
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| Synonyms: | neutrocyte, neutrophil leucocyte, neutrophil leukocyte, neutrophilic leucocyte, neutrophilic leukocyte, PMN, polymorphonuclear leucocyte, polymorphonuclear leukocyte, polymorphonuclear neutrophil, polynuclear neutrophilic leucocyte, polynuclear neutrophilic leukocyte |
| Definition: | Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. |
| Ontology: | Anatomy Ontology [ZFA:0009327] |
| chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 3.4.22.36 (caspase-1) inhibitor |
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| Synonyms: | caspase-1 (EC 3.4.22.36) inhibitor, caspase-1 (EC 3.4.22.36) inhibitors, caspase-1 inhibitor, caspase-1 inhibitors, EC 3.4.22.36 (caspase-1) inhibitors, EC 3.4.22.36 inhibitor, EC 3.4.22.36 inhibitors, ICE inhibitor, ICE inhibitors, interleukin 1 converting enzyme inhibitor, interleukin 1 converting enzyme inhibitors, interleukin 1beta converting enzyme inhibitor, interleukin 1beta converting enzyme inhibitors, interleukin 1beta precursor proteinase inhibitor, interleukin 1beta precursor proteinase inhibitors, interleukin 1beta-converting endopeptidase inhibitor, interleukin 1beta-converting endopeptidase inhibitors, interleukin 1beta-converting enzyme inhibitor, interleukin 1beta-converting enzyme inhibitors, interleukin-1 beta convertase precursor inhibitor, interleukin-1 beta convertase precursor inhibitors, interleukin-1beta convertase inhibitor, interleukin-1beta convertase inhibitors, interleukin-1beta converting enzyme inhibitor, interleukin-1beta converting enzyme inhibitors, interleukin-1beta precursor proteinase inhibitor, interleukin-1beta precursor proteinase inhibitors, precursor interleukin-1beta converting enzyme inhibitor, precursor interleukin-1beta converting enzyme inhibitors, pro-interleukin 1beta proteinase inhibitor, pro-interleukin 1beta proteinase inhibitors, prointerleukin 1beta protease inhibitor, prointerleukin 1beta protease inhibitors, protease A inhibitor, protease A inhibitors, protease VII inhibitor, protease VII inhibitors |
| Definition: | Any EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the activity of caspase-1 (EC 3.4.22.36). |
| Ontology: | ChEBI [CHEBI:76795] ( EBI ) |
| chemical treatment by environment: metronidazole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | metronidazole |
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| Synonyms: | 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum |
| Definition: | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
| Ontology: | ChEBI [CHEBI:6909] ( EBI ) |
| Publication: | Tyrkalska et al., 2019 |
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