ZFIN ID: ZDB-EXP-200511-3
Experiment Conditions Description: perforation: retina, chemical treatment: 10058-F4
perforation: retina
Name: perforation
Synonyms:
Definition: Experimental condition in which a hole or break in the membranes of an organ or structure of the body is created.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000178]
Name: retina
Synonyms: retinas
Definition: Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup.
Ontology: Anatomy Ontology [ZFA:0000152]
chemical treatment: 10058-F4
Name: chemical treatment
Synonyms:
Definition: Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000111]
Name: 10058-F4
Synonyms: 10058F4, 5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one, 5-(4-ethylbenzylidene)-2-sulfanylidene-1,3-thiazolidin-4-one, 5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one, 5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Definition: A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase.
Ontology: ChEBI [CHEBI:149696]  ( EBI )
Publication: Mitra et al., 2019