| ZFIN ID: ZDB-EXP-181228-3 |
Experiment Conditions Description: chemical treatment by environment: CFTRinh-172, chemical treatment by environment: afimoxifene
| chemical treatment by environment: CFTRinh-172 |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | CFTRinh-172 |
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| Synonyms: | (inh)-172, 3-[(3-trifluoromethyl)phenyl]-5-[(3-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, 4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid, 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl]-4-thiazolidinone, C2992_SIGMA, CFTR(inh)-172, Cystic fibrosis transmembrane conductance regulator inhibitor CFTR(inh)-172, cystic fibrosis transmembrane regulator inhibitor 172 |
| Definition: | A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane conductance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene. |
| Ontology: | ChEBI [CHEBI:131686] ( EBI ) |
| chemical treatment by environment: afimoxifene |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | afimoxifene |
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| Synonyms: | 4-hydroxytamoxifen, 4-monohydroxytamoxifen, 4-OHT, afimoxifene |
| Definition: | A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. |
| Ontology: | ChEBI [CHEBI:44616] ( EBI ) |
| Publication: | Dasgupta et al., 2018 |
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