| ZFIN ID: ZDB-EXP-180820-3 |
Experiment Conditions Description: chemical treatment: arachidonic acid, chemical treatment: aspirin-based probe AP
| chemical treatment: arachidonic acid |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | arachidonic acid |
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| Synonyms: | (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoic acid, (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid, (5Z,8Z,11Z,14Z)-Icosatetraenoic acid, AA, all-cis-5,8,11,14-eicosatetraenoic acid, ARA, Arachidonate, Arachidonic acid, Arachidonsaeure, cis-5,8,11,14-Eicosatetraenoic acid, cis-Delta(5,8,11,14)-eicosatetraenoic acid |
| Definition: | A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14. |
| Ontology: | ChEBI [CHEBI:15843] ( EBI ) |
| chemical treatment: aspirin-based probe AP |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | aspirin-based probe AP |
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| Synonyms: | 2-(1,3-benzothiazol-2-yl)-4-fluorophenyl 2-(acetyloxy)benzoate, 2-(1,3-benzothiazol-2-yl)-4-fluorophenyl 2-acetoxybenzoate, 2-(1,3-benzothiazol-2-yl)-4-fluorophenyl salicylate, probe AP |
| Definition: | A benzoate ester resulting from the formal condensation of the carboxy group of acetylsalicylic acid with the phenolic hydroxy group of 2-(1,3-benzothiazol-2-yl)-4-fluorophenol. The latter is a fluorophore which is to the aspirin moiety via an H2O2-responsive bond. It can be used as probe for imaging H2O2 (overproduction of H2O2 causes oxidative stress and is characteristic of vascular diseases). In contrast to arylboronat-based probes, it shows high specificity for H2O2 over peroxynitrite (which is much more reactive than H2O2, but exists at much lower abundance). |
| Ontology: | ChEBI [CHEBI:141699] ( EBI ) |
| Publication: | Wang et al., 2017 |
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