| ZFIN ID: ZDB-EXP-131218-10 |
Experiment Conditions Description: chemical treatment: tanespimycin
| chemical treatment: tanespimycin |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | tanespimycin |
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| Synonyms: | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, 17-AAG, 17-allylaminogeldanamycin, 17-demethoxy-17-(2-propenylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-N-allylamino-17-demethoxygeldanamycin, 17AAG, NSC 330507, NSC-330507, tanespimycin, tanespimycina, tanespimycine, tanespimycinum |
| Definition: | A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects. |
| Ontology: | ChEBI [CHEBI:64153] ( EBI ) |
| Publication: | Sheehan-Rooney et al., 2013 |
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