| ZFIN ID: ZDB-EXP-260710-1 |
Experiment Conditions Description: primary cell culture: cardiac muscle cell, chemical treatment by environment: Istaroxime
| primary cell culture: cardiac muscle cell |
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| Name: | primary cell culture |
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| Synonyms: | |
| Definition: | In vitro culture condition in which an embryo or adult fish is dissociated to a single cell suspension. The analysis is made on this cell culture. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000145] |
| Name: | cardiac muscle cell |
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| Synonyms: | cardiac muscle cells, cardiac myocyte, cardiomyocyte |
| Definition: | |
| Ontology: | Anatomy Ontology [ZFA:0009316] |
| chemical treatment by environment: Istaroxime |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | Istaroxime |
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| Synonyms: | (3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 469045, PST-2744, PST2744 |
| Definition: | A steroidal drug that improves cellular calcium cycling that inhibits sodium-potassium ATPase and stimulates sarcoplasmic reticulum calcium ATPase isoform 2a (SERCA2alpha). |
| Ontology: | ChEBI [CHEBI:747876] ( EBI ) |
| Publication: | Kamel et al., 2021 |
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